4475-23-4Relevant academic research and scientific papers
Ion-Neutral Complex Intermediate for Loss of Water from Fatty Acid Carboxylates
Jensen, Nancy J.,Haas, George W.,Gross, Michael L.
, p. 423 - 427 (1992)
Fatty acid carboxylates desorbed into the gas phase by fast atom bombardment (FAB) undergo both metastable-ion and collisionally activated dissociation (CAD) to eliminate water.Upon CAD, the water elimination competes with charge-remote fragmentation.Deuterium labeling results are in accord with the elimination occurring via an ion-neutral complex involving hydroxide ion and neutral ketene.Evidence that the precursor of the ion-neutral complex is the enol form of the carboxylate was obtained by forming the enolate directly by decarboxylation of appropriate dicarboxylic acids.The (1-) ions of these species undergo a more facile elimination of water than do carboxylates desorbed directly upon FAB.
LPA RECEPTOR AGONISTS AND ANTAGONISTS
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Page/Page column 53, (2010/05/14)
Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.
