448211-96-9Relevant academic research and scientific papers
Are PhAcOZ and Nsc suitable Nα-protecting groups for protease-catalysed peptide synthesis?
Braun,Kuhl
, p. 310 - 312 (2007/10/03)
Protecting groups are necessary chemical tools in peptide synthesis. In protease-catalysed peptide synthesis they exert influence both on enzyme-substrate binding and on solubility. In this study, we have investigated the usability of various PhAcOZ- and Nsc-protected amino acids for protease-catalysed peptide synthesis. PhAcOZ-protected peptides were obtained in high yields using papain and thermolysin. In contrast to this, Nsc, as a base-labile ct-amino protecting group, is not suitable for biocatalytic synthesis under the conditions employed.
