160422-18-4Relevant academic research and scientific papers
2-(4-Nitrophenyl)sulfonylethoxycarbonyl (Nsc) Group As a Base-Labile α-Amino Protection for Solid Phase Peptide Synthesis
Samukov, Vladimir V.,Sabirov, Aydar N.,Pozdnyakov, Pavel I.
, p. 7821 - 7824 (1994)
Base-labile 2-(4-nitrophenylsulfonyl)ethoxycarbonyl (Nsc) group is proposed for a temporary α-amino protection in the solid phase peptide synthesis.Nsc-Group is cleaved by organic bases in aprotic solvents under mild conditions similar to that used for Fmoc-group.Several Nα-Nsc amino acids are prepared and used in the solid phase synthesis of the fragment 307-318 of S-protein from bovine eye retina.
Are PhAcOZ and Nsc suitable Nα-protecting groups for protease-catalysed peptide synthesis?
Braun,Kuhl
, p. 310 - 312 (2007/10/03)
Protecting groups are necessary chemical tools in peptide synthesis. In protease-catalysed peptide synthesis they exert influence both on enzyme-substrate binding and on solubility. In this study, we have investigated the usability of various PhAcOZ- and Nsc-protected amino acids for protease-catalysed peptide synthesis. PhAcOZ-protected peptides were obtained in high yields using papain and thermolysin. In contrast to this, Nsc, as a base-labile ct-amino protecting group, is not suitable for biocatalytic synthesis under the conditions employed.
