448216-71-5Relevant academic research and scientific papers
One-pot synthesis of alkyl 3-aryl-2-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoates
Pokhodylo,Savka,Obushak
, p. 734 - 737 (2017/07/07)
Reaction of 3-aryl-2-bromopropanoic acids esters, products of the Meerwein arylation, with sodium azide afforded alkyl 2-azido-3-arylpropanoates. The latter react with ethyl acetoacetate and phenylacetylene to form 1,2,3-triazole derivatives. A one-pot me
Synthesis and reaction of 2-mercapto-3-arylpropanoic acids
Pokhodylo, Nazariy T.,Matiychuk, Vasyl S.,Obushak, Mykola D.
experimental part, p. 850 - 858 (2012/08/07)
Two synthetic pathways for the preparation of 2-mercapto-3-arylpropanoic acids were developed. First, by the reaction of arenediazonium bromides with acrylic esters in the presence of CuBr, alkyl (2-bromo-3-aryl)propanoates were formed. Their cyclization with thiourea produced 5-(R-benzyl)-2-imino-4- thiazolidinones, which yielded 3-aryl-2-mercaptopropanoic acids by alkaline hydrolysis. Second, direct Meerwein arylation of acrylates in the presence of S-nucleophile (NaSH) allowed isolation of 3-phenyl-2-mercaptopropanoic acid in 8% yield. Such acids were used for cyclization with cyanoguanidine and phenyl isothiocyanate yielding 1-[5-(R-benzyl)-4-oxo-1,3-thiazolidin-2-ylidene] guanidines and new 5-(R-benzyl)-3-phenyl-2-thioxo-1,3-thiazolidin-4-one (rhodanine) derivatives correspondingly. Copyright Taylor and Francis Group, LLC 2012.
Synthesis of heterocycles from arylation products of unsaturated compounds: XIII. 5-R1-benzyl-2-(R2-2-pyridylimino)thiazolidin-4-ones
Matiichuk,Obushak,Tsyalkovskii
, p. 1050 - 1054 (2007/10/03)
Meerwein reactions of arenediazonium bromides with methyl and ethyl acrylates gave 3-aryl-2-bromopropionic acid esters which were subjected to cyclocondensation with N-(2-pyridyl)- and N-(6-methyl-2-pyridyl) thioureas to obtain 5-R1-benzyl-2-(R
Synthesis of heterocycles on the basis of arylation products of unsaturated compounds. 11.1 5-R-benzyl-2-iminoselenazolidin-4-ones from ethyl 3-aryl-2-bromopropanoates
Obushak, Mykola D.,Matiychuk, Vasyl S.,Tsyalkovsky, Volodymyr M.,Voloshchuk, Roman M.
, p. 107 - 113 (2007/10/03)
Ethyl 3-aryl-2-bromopropanoates 2a-p were prepared by reaction of ethyl acrylate with arenediazonium bromides 1a-p in the presence of CuBr (Meerwein arylation). These compounds react with selenourea to form 5-R-benzyl-2- iminoselenazolidin-4-ones 4a-p. Compounds 4a-p hydrolyze into the corresponding selenazolidin-2,4-diones.
