44843-50-7Relevant academic research and scientific papers
Synthesis method of synthetic intermediate methyl phosphite monoester of glufosinate ammonium
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Paragraph 0067; 0068, (2018/09/08)
The invention belongs to the technical field of synthesis of glufosinate ammonium and in particular relates to a synthesis method of a synthetic intermediate methyl phosphite monoester of glufosinateammonium. Aiming at the common problem of an existing methyl phosphite monoester synthesis method that the cost is too high so that the existing methyl phosphite monoester synthesis method is not applicable to large-scale industrial production, the synthesis method provided by the technical scheme comprises the following steps: [1], enabling methylphosphonothioic dichloride to react with a hydroxyl compound under the action of an alkali A, so as to obtain diethyl methylphosphonothionate; [2], dissolving the diethyl methylphosphonothionate into a solvent B to prepare a diethyl methylphosphonothionate solution; carrying out hydrolysis reaction under the action of an alkali B to generate methylphosphonothioic monoester; [3], dissolving the methylphosphonothioic monoester into a solvent C to prepare a methylphosphonothioic monoester solution; carrying out desulfurization reaction on the methylphosphonothioic monoester solution under the action of a catalyst to prepare the methyl phosphitemonoester. The synthesis method provided by the invention is applicable to a glufosinate ammonium synthesis industry.
Preparation method of glufosinate ammonium intermediate methylphosphinic acid monoester
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Paragraph 0040; 0045; 0046; 0048; 0050; 0052, (2018/07/15)
The invention discloses a preparation method of glufosinate ammonium intermediate methylphosphinic acid monoester. The preparation method includes the steps that o-methylphosphinic chloride and sulfohydrate are made to react under the alkaline condition to obtain methyl thiophosphonate, and methyl thiophosphonate is subjected to desulfurization reaction to obtain the glufosinate ammonium intermediate methylphosphinic acid monoester. The preparation method has the advantages that raw materials can be easily obtained, construction of P-C bonds is not needed, the process operation is simple and convenient, the production cost and the requirement on equipment are reduced, and the preparation method is suitable for industrial production.
