44915-39-1

Usage

Uses

Used in Pharmaceutical Industry:
(2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER is used as a precursor for the synthesis of complex molecules, such as drugs, due to its chemical composition and reactivity.
Used in Chemical Industry:
(2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER is used as a reagent in organic synthesis, facilitating the creation of a wide range of chemical compounds.
Used as a Chemical Intermediate:
In the production of other compounds, (2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER serves as a crucial intermediate, contributing to the development of various chemical products.
Overall, (2-CYANO-ETHYLAMINO)-ACETIC ACID METHYL ESTER's applications in the chemical and pharmaceutical industries are extensive, owing to its unique structure and functional groups that enable it to participate in numerous synthetic processes.

Upstream product

• 107-13-1 acrylonitrile 
• 616-34-2 methoxycarbonylmethylamine 
• 5680-79-5 glycine ethyl ester hydrochloride 
• 67-56-1 methanol 
• 3088-42-4 N-(2-cyanoethyl)glycine 

Downstream Products

• 398491-59-3 3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 
• 398495-65-3 3-amino-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester 
• 761443-69-0 5-tert-butyl 1-ethyl 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-4,6-dihydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate 
• 850997-37-4 ethyl 5-(2,6-diethylphenylcarbamoyl)-3-[4-(4-methylpiperazin-1-yl)benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylate 
• 175463-32-8 3-cyano-4-oxopyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors

Two series of 3-aminopyrazole compounds including 24 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and 16 pyrazolo[3,4-b]pyridines were synthesized and evaluated against HCT116, A549, and A2780 tumor cell lines. Among them, three compounds were found to have the ideal anti-proliferative activities in vitro. Docking experiments showed that the novel pyrazolo[3,4-b]pyridines share the similar interaction mode with Aurora-A kinase as PHA739358.

(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Replacement of the triazolopiperazine ring of sitagliptin (DPP-4 IC50 = 18 nM) with 3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one gave dipeptidyl peptidase IV (DPP-4) inhibitor 1 which is potent (DPP-4 IC50 = 2.6 nM), selective, and ef

Potent and selective aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition

Potent and selective Aurora kinase inhibitors were identified from the combinatorial expansion of the 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole bi-cycle, a novel and versatile scaffold designed to target the ATP pocket of protein kinases. The most potent c

SYNTHESIS OF N-2-CARBOXYETHYL-N-PHOSPHONOMETHYLGLYCINE

A method was developed for the synthesis of N-2-carboxyethyl-N-phosphonomethylglycine by phosphonomethylation of N-cyanoethylglycine by the Kabachnik-Fields method, followed by hydrolysis.The reaction of cyanoethylglycine with dimethyl phosphite and a 35percent aqueous solution of formaldehyde was studied by 31P NMR spectroscopy, and the structures of the main and side-reaction products were established.It was shown that the reaction kinetics is described by a second-order reaction.