449152-74-3Relevant academic research and scientific papers
A click chemistry approach to pleuromutilin conjugates with nucleosides or acyclic nucleoside derivatives and their binding to the bacterial ribosome
Lolk, Line,P?hlsgaard, Jacob,Jepsen, Anne Sofie,Hansen, Lykke H.,Nielsen, Henrik,Steffansen, Signe I.,Sparving, Laura,Nielsen, Annette B.,Vester, Birte,Nielsen, Poul
supporting information; experimental part, p. 4957 - 4967 (2009/09/25)
Pleuromutilin and its derivatives are antibacterial drugs that inhibit protein synthesis in bacteria by binding to ribosomes. To promote rational design of pleuromutilin based drugs, 19 pleuromutilin conjugates with different nucleoside fragments as side
Heterocyclic nucleoside analogues: Design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles
Lee, Yoon-Suk,Byeang, Hyean Kim
, p. 1395 - 1397 (2007/10/03)
We have designed and synthesized novel antiviral nucleoside analogues, which consist of isoxazole rings as modified sugars and nucleobases (thymine, uracil, and 5-fluorouracil) with a methylene linker between them. These compounds represent a new class of
