449174-90-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Fluoro-benzyl)-piperazine hydrochloride is used as a building block for the synthesis of biologically active compounds and pharmaceuticals, due to its unique structure and properties that allow for the creation of diverse molecules with potential therapeutic applications.
Used in Medicinal Chemistry Research:
1-(4-Fluoro-benzyl)-piperazine hydrochloride is used as a research chemical for studying the structure-activity relationships of piperazine-based compounds. This helps in understanding their pharmacological properties and can lead to the development of new drugs with improved efficacy and safety profiles.
Used in Drug Development:
As a compound with potential pharmaceutical applications, 1-(4-Fluoro-benzyl)-piperazine hydrochloride is utilized in drug development processes. Its incorporation into the synthesis of new drug candidates can contribute to the discovery of novel therapeutic agents with specific targeting and treatment capabilities.

Upstream product

• 110-85-0 piperazine 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 77278-77-4 4-(4-fluorobenzyl)piperazine-1-tert-butoxycarbonyl ester 
• 142-64-3 piperazine dihydrochloride 
• 6091-62-9 piperazine dihydrochloride hydrate 
• 7542-23-6 piperazine hydrochloride 

Relevant academic research and scientific papers

Simplified procedure for general synthesis of monosubstituted piperazines-from a batch reaction vessel to a flow (microwave) reactor

We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied the possibilities of microwave acceleration of given synthetic reactions to make them even more efficient. Our research proceeded from a simple batch technique to the construction of a flow microwave reactor prototype and resulted in promising findings which are summarized and discussed in the article.

Novel bicyclic nitroimidazole carbamate compounds, process for preparation thereof and pharmaceutical composition for preventing or treating tuberculosis containing the same as an active ingredient

A bicyclic nitroimidazole carbamate compound represented by chemical formula 1, an optical isomer thereof or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition for preventing or treating tuberculosis disease containing the same as an active ingredient. Chemical Formula 1. In Chemical Formula 1, R. 1 And R2 Are as defined in the description of the invention. The bicyclic nitroimidazole carbamate compounds of the present invention exhibit excellent inhibitory effects on vitality and non-active tuberculosis. The compounds can be useful in the treatment of tuberculosis.

Aralkyl-alcohol peiperazine derivatives adn their uses as antidepressant

Aryl alkanol piperazine derivatives of the formula and pharmaceutical compositions comprising the same. Also disclosed are methods for treating depression using the pharmaceutical compositon. Compounds of the invention have excellent dual inhibitory actions to the uptake of the mono-amines neurotransmitter, good antidepressant activities and minor side effects.

Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers

The current research aimed to investigate the importance of the heterocyclic ring system in the structure of the cardiovascular drug diltiazem for its calcium channel blocking activity. The manuscript describes the design, synthesis, and biological testin

Calcium channel blockers

The invention involves the identification of a family of compounds which block calcium channels. The compounds can be formulated in pharmaceutical carriers and administered to subjects. The compounds are useful for treating disorders associated with calci