7542-23-6

Basic information

• Product Name: piperazinium chloride
• Synonyms: piperazinium chloride;NISTC7542236
• CAS NO: 7542-23-6
• Molecular Formula: C₄H₁₁N₂*Cl
• Molecular Weight: 122.59654
• EINECS: 231-422-5
• Mol File: 7542-23-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: piperazinium chloride(CAS DataBase Reference)
• NIST Chemistry Reference: piperazinium chloride(7542-23-6)
• EPA Substance Registry System: piperazinium chloride(7542-23-6)

Safety Data

• Hazardous Substances Data: 7542-23-6(Hazardous Substances Data)

Usage

InChI:InChI=1S/C4H10N2.ClH/c1-2-6-4-3-5-1;/h5-6H,1-4H2;1H

Upstream product

• 290-37-9 1,4-pyrazine 
• 142-64-3 piperazine dihydrochloride 
• 110-85-0 piperazine 
• 75-36-5 acetyl chloride 

Downstream Products

• 100861-65-2 1-(3-o-tolyloxy-propyl)-piperazine 
• 2759-28-6 1-phenylmethylpiperazine 
• 956-61-6 1-(4-tert-butylbenzyl)piperazine 
• 5321-49-3 4-(phenethyl)piperazine 
• 40675-81-8 1-naphthalen-1-ylmethyl-piperazine 
• 29331-48-4 N,N'-bis(antipyryl-4-methylene)-piperazine 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 138768-65-7 C₁₈H₁₈N₆ 
• 57260-68-1 2-piperazin-1-yl-1H-benzoimidazole 
• 55745-83-0 2-piperazinobenzothiazole 
• 42270-37-1 1-thiazol-2-yl-piperazine 
• 131136-87-3 1,4-bis(2-thiazolyl)-1,4-diazacyclohexane 
• 153025-29-7 6-chloro-2-piperazin-1-yl-benzothiazole 
• 863001-13-2 C₁₈H₁₄Cl₂N₄S₂ 

Relevant articles and documents

Can Heteroarenes/Arenes Be Hydrogenated Over Catalytic Pd/C Under Ambient Conditions?

Hydrogenation of over a dozen aromatic compounds, including both heteroarenes and arenes, over palladium on carbon (Pd/C, 1–100 molpercent) with H2-balloon pressure at room temperature is reported. Analyses using pyridine as a model substrate revealed that acetic acid was the best solvent, as using only 1 molpercent Pd/C provided piperidine quantitatively. Substrate scope analysis and density functional theory calculations indicated that reaction rates are highly dependent on frontier molecular orbital characteristics and the steric bulkiness of substituents. Moreover, the established method was used for the concise synthesis of the anti-Alzheimer drug donepezil (Aricept?).

A convenient synthesis of 1-aralkyl-4-benzylpiperazine derivatives

An efficient two-step route was developed for the synthesis of 1-aralkyl-4-benzylpiperazine derivatives by a Blanc reaction and alkylation. The key intermediate, N-benzylpiperazine, was prepared in an excellent yield by direct benzylation of commercially available piperazine under metal-free conditions.

PROCESS FOR PRODUCING PIPERAZINE DERIVATIVE

A process for producing a compound represented by the following general formula or its salt: (1) wherein A represents a lower alkylene group; characterized by comprising reacting a single salt of piperazine represented by the following formula: (2) wherein XH represents a salt-forming organic acid or inorganic acid; with a compound represented by the following general formula: (3) wherein A has the same meaning as defined above; and Y represents an acid residue.