450-14-6

Usage

Uses

Used in Pharmaceutical Industry:
Corypalline is used as a potential therapeutic agent for pain management due to its antinociceptive properties. It is being studied for its ability to alleviate pain, which could be beneficial in the development of new treatments for various painful conditions.
Corypalline is also used as a potential therapeutic agent for sleep disorders because of its sedative properties. Corypalline's calming effects are of interest for researchers looking to develop new treatments for insomnia and other sleep-related issues.
As research on corypalline continues, its applications may expand into other areas of medicine, depending on the results of ongoing pharmacological studies and the discovery of additional therapeutic benefits.

InChI:InChI=1/C11H15NO2/c1-12-4-3-8-6-11(14-2)10(13)5-9(8)7-12/h5-6,13H,3-4,7H2,1-2H3

Upstream product

• 576-26-1 2.6-dimethylphenol 
• 19373-80-9 p-quinol acetate 
• 20938-53-8 (+/-)-orientaline 
• 36455-27-3 (+/-)-6-hydroxy-7-methoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1472-62-4 N-methylcoclaurine 
• 108-24-7 acetic anhydride 
• 108-95-2 phenol 
• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 

Downstream Products

• 87339-97-7 7-acetoxy-6-methoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline 
• 88493-75-8 o-acetyl-1-phenylcorypalline 
• 117452-45-6 O,O'-diacetyl-8,8'-bicorypallyl 
• 4667-10-1 6-methoxy-2-methyl-1-phenyl-1,2,3,4-tetrahydro-isoquinolin-7-ol 
• 14510-48-6 corypalline dimer 

Relevant academic research and scientific papers

Berberis ALKALOIDS. XV. STRUCTURE OF BARGUSTANINE

Bargustanine (I), belonging to a new type of isoquinoline alkaloids, has been isolated from the phenolic fraction of the total alkaloids from the roots of Berberis vulgaris L.Its structure has been established by chemical and spectral methods.

BIOMIMETIC OXIDATIONS OF BENZYLISOQUINOLINE ALKALOUDS. I. THE PEROXIDASE AND ASCORBIC OXIDASE-CATALYSED OXIDATION

The enzyme peroxidase behaves as a mixed-function oxidase toward the benzylisoquinoline alkaloid nucleus, giving rise to various phenoxy radicals depending on the substrate.These give either C(4) hydroxylation or C(5') hydroxylation and cyclisation to an aporphine, or cleavage of the C(1)-C(9) bond.

NEW SYNTHESIS OF ISOQUINOLINE ALKALOIDS, THALIFOLINE, CORYPALLINE, AND CHERYLLINE

Isoquinoline alkaloids, thalifoline, corypalline, and cherylline, were synthesised by application of the cyclisation reaction of β-phenyl-ethyl isocyanate to N-methylisoquinoline lactam with Magic Methyl and the regioselective cleavage reaction of aromatic methoxyl groups with methionine and methanesulphanic acid.