450-29-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-FLUORO-PHENYL)-2-METHYL-THIAZOLE is used as a building block in the synthesis of various pharmaceuticals for its diverse biological activities, including antimicrobial, antifungal, and antitumor properties. Its unique chemical structure allows for the development of new molecules with improved properties, enhancing their therapeutic efficacy.
Used in Agrochemical Industry:
4-(4-FLUORO-PHENYL)-2-METHYL-THIAZOLE is also used as a building block in the synthesis of agrochemicals, leveraging its antimicrobial and antifungal properties to develop new compounds for crop protection and disease management. Its potential in this industry contributes to the development of innovative and effective solutions for agricultural challenges.

InChI:InChI=1/C10H8FNS/c1-7-12-10(6-13-7)8-2-4-9(11)5-3-8/h2-6H,1H3

Upstream product

• 62-55-5 thioacetamide 
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• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 329-79-3 1-(4-fluorophenyl)ethanone oxime 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Access to Thiazole via Copper-Catalyzed [3+1+1]-Type Condensation Reaction under Redox-Neutral Conditions

A new strategy for thiazoles via copper-catalyzed [3+1+1]-type condensation reaction from oximes, anhydrides and potassiumthiocyanate (KSCN) is developed herein. The transformation has good functional group tolerance and various thiazoles were formed smoothly in good to excellent yields under mild reaction conditions. This process involves copper-catalyzed N-O/C-S bond cleavages, activation of vinyl sp2 C-H bond, and C-S/C-N bond formations which are under redox-neutral conditions as well as operational simplicity.

A rapid and high-yielding synthesis of thiazoles and aminothiazoles using tetrabutylammonium salts

A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of tetrabutylammonium hexafluorophosphate (Bu4NPF6) at room temperature was developed. The products having high yields were formed rapidly (within 15 min). The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis data. The Japan Institute of Heterocyclic Chemistry.

KINASE INHIBITORS

The present invention provides kinase inhibitors of Formula I.