450409-01-5

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 54429-62-8 (E)-3-(3,4-bis(benzyloxy)phenyl)acrylic acid 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 71038-25-0 methyl (E)-3-(3,4-bis(benzyloxy)phenyl)acrylate 

Downstream Products

• 450409-33-3 (E)-3-(3,4-Bis-benzyloxy-phenyl)-N-[3-(6-{3-[(E)-3-(3,4-bis-benzyloxy-phenyl)-acryloylamino]-propyl}-[1,6]diazecan-1-yl)-propyl]-acrylamide 

Relevant academic research and scientific papers

Very short and efficient syntheses of the spermine alkaloid kukoamine A and analogs using isolable succinimidyl cinnamates

Direct selective acylation of the primary amino functions of spermine and spermidine with a variety of isolable succinimidyl cinnamates, followed by catalytic hydrogenation, gave high yields of the spermine alkaloid kukoamine A and analogs suitable for structure-activity relationship studies. Suitable succinimidyl cinnamates were readily obtained through Wittig reaction of aromatic aldehydes with the ylides Ph3P=CRCO2Me, followed by saponification and activation with N-hydroxysuccinimide in the presence of N,N'-dicyclohexylcarbodiimide. Copyright

Simple syntheses of cyclic polyamines using selectively N-tritylated polyamines and succinic anhydride

Treatment of selectively N-tritylated spermidine and spermine derivatives with succinic anhydride, followed by PyBrOP-mediated intramolecular amide bond formation and LiAlH4 reduction, allows for an easy and general entry to cyclic polyamine derivatives.