450844-55-0Relevant articles and documents
Synthesis of a novel farnesyl transferase inhibitor, ABT-100; Selective preparation of a stereogenic tertiary carbinol
Rozema, Michael J.,Kruger, Albert W.,Rohde, Bridget D.,Shelat, Bhadra,Bhagavatula, Lakshmi,Tien, James J.,Zhang, Weijiang,Henry, Rodger F.
, p. 4419 - 4425 (2007/10/03)
A stereoselective synthesis of ABT-100 1, a novel farnesyl transferase inhibitor, is described. The key step involves a stereoselective addition of the heterocyclic zinc reagent 10 to chiral α-keto ester 9 in >10:1 diastereoselectivity using menthol as th