4512-98-5

Upstream product

• 74877-28-4 (Z)-3-(4-Methoxy-phenyl)-3-phenylselanyl-acrylic acid 
• 1394284-81-1 1-(2-chlorophenyl)-3-(4-methoxyphenyl)prop-2-yn-1-one 
• 6630-33-7 ortho-bromobenzaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 4671-91-4 4H-selenochromen-4-one 
• 3463-32-9 1-(2-bromophenyl)-2-propyn-1-one 
• 222713-56-6 1-(2-bromophenyl)-2-propyn-1-ol 
• 645-96-5 Benzeneselenol 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 

Relevant academic research and scientific papers

Stereoselective Synthesis of Z-Vinyl Selenides Through the Reaction of Sodium Selenide with Organic Halides and Alkynes

A practical synthetic approach to the stereoselective synthesis of Z-vinyl selenides is described through the reaction of sodium selenide with organic halides, followed by the addition to alkynes. The reaction conditions were also successfully applied to

A novel selenoflavone compound as anti-obesity agent

The present invention relates to a process for producing a novel selenoflavone compound and a pharmaceutical composition for preventing or treating obesity comprising the selenoflavone compound. In the present invention, selenoflavone, especially PMSF, which has never been synthesized due to synthetic difficulties can be synthesized through palladium-catalyzed direct C-H arylation. Since the synthesized selenoflavone has an improving effect related to activation of brown adipose tissue (BAT), the selenoflavone can be used in the composition for prevention and treatment of obesity.COPYRIGHT KIPO 2018

Efficient synthesis of polymethoxyselenoflavones via regioselective direct C-H arylation of selenochromones

Substantial research has suggested that the configuration and the total number of functional groups on flavones influence their bioactivity. To investigate the changes in the biological activities of selenoflavones in relationship to structural changes, the development of a generally applicable synthetic method was a key. Until now, an efficient pathway for palladium-catalyzed direct arylation with the selenocyclic enone systems is not known in the literature. We herein introduce a simple direct C-H arylation of two difficult coupling partners, selenochromones and electron-rich aryl bromide, affording diverse polymethoxyselenoflavones with great efficiency and high selectivity.

Regiochemical Control of the Addition of Aryl Selenols and Aryl Thiols to the Triple Bond of Arylpropiolates. Synthesis of Seleno- and Thioflavones and Seleno- and Thioaurones

Addition of aryl selenols and aryl thiols to arylpropiolates under basic conditions followed by saponification gave exclusively β-substituted cinnamates of predominant Z sterochemistry.Neat solutions of aryl selenols or aryl thiols and arylpropiolates aft