4513-42-2Relevant academic research and scientific papers
Tandem type polymerization. Synthesis and characterization of ordered poly(amide-thioether) from 2,6-dichlorophenyl methacrylate, 4,4′-thiobis(benznenethiol), and 4,4′-oxydianiline
Tsuchiya, Kousuke,Shibasaki, Yuji,Ueda, Mitsuru
, p. 1815 - 1818 (2003)
Ordered poly(amide-thioether) (17) was prepared by tandem type polymerization of 2,4-dichlorophenyl acrylate (11), 4,4′-thiobis(benznenthiol) (12), and 4,4′-oxydianiline (16). The polymerization was carried out by mixing all monomers in the presence of catalytic amounts of triethylamine (TEA) and 1-hydroxybenzotriazole (HOBt) in 1-methyl-2-pyrrolidinone (NMP) at 20 °C for 2 h and then 80 °C for 2 days, yielding polymer 17 with a number-average molecular weight (Mn) of 25 000. Authentic ordered poly(amide-thioether) (18) was prepared to verify the structure of polymer 17. The microstructure of polymers obtained was investigated by 1H and 13C NMR spectroscopy, and it has been found the polymer obtained has the expected ordered structure. Furthermore, model reactions were studied in detail to demonstrate the feasibility of ordered polymer formation.
As neuroprotective agents of pharmaceutical compounds
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Paragraph 0524; 0525; 0526; 0527, (2019/06/26)
The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.
SUBSTITUTED BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS
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Paragraph 00194, (2017/01/23)
Benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethyfase, including LSD1 and LSD2; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1 and/or LSD2.
Biofilm Resistant Polymer Materials
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Page/Page column 11-12, (2009/12/24)
The present invention relates to compounds and materials that reduce the accumulation of microorganisms on a surface by interfering with the attachment of the organisms to the surface. The compounds and materials of the present invention are thus useful in preventing the formation of biofilms. The compounds of the present invention may be either adhered to a surface or integrated within a polymer. Surfaces coated by the present invention are resistant to biofilm formation, in part due to the smoothness of the surface coated with the present invention.
FURTHER STUDY OF ESTERTIN TRICHLORIDES, Cl3SnCH2CH2CO2R. LEWIS ACIDITY TOWARDS ACETONITRILE. CRYSTAL STRUCTURE OF Cl3SnCH2CH2CO2Pr-i
Howie, R. Alan,Paterson, Eric S.,Wardell, James L.,Burley, Joseph W.
, p. 301 - 308 (2007/10/02)
Crystals of Cl3SnCH2CH2CO2Pr-i are orthorombic, space group P212121 with a 9.638(6), b 10.004(7) and c 12.848(8) Angstroem.The tin atom is five-coordinate with two chlorines and carbon equatorial and the remaining chlorine and the carbonyl oxygen axial, in a distorted trigonal-bipyramidal arrangement: (Sn-Cl)ax 2.389(3), average (Sn-Cl)eq 2.320(2), Sn-C 2.142(9), Sn-O 2.337(5) Angstroem.Apart from the equatorial chlorine and the terminal carbons in the isopropyl group, all non-hydrogen atoms are essentially coplanar.The molecule approaches C2v symmetry although not constrained to do so by the crystallographic space group.In MeCN solution, the compounds Cl3SnCH2CH2CO2R (I, R = Me, Pr-i, C6H4X (X = p-MeO, H, p-Cl, o-MeO) or C6H3Cl2-2,4) form as equilibrium mixtures of 1/1 and 2/1 MeCN/1 complexes; the chelate ring is broken in the 2/1 complexes.Equilibrium constants indicate that the strength of the intramolecular Sn-O coordination I increases with the electron releasing ability of the R group.
