4514-33-4Relevant academic research and scientific papers
A method for synthesis of hydantoin derivatives (by machine translation)
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Paragraph 0016; 0017; 0018, (2018/08/28)
The present invention provides a method for synthesis of hydantoin derivatives, the end-of alkynes and isocyanate as reaction raw material, carbene cuprous chloride as catalyst, high-efficient for synthesis of hydantoin derivatives: (Z)- 5 - methylene - 1, 3 - dialkyl - 2, 4 - imidazoline dione. The method of mild reaction conditions, high yield, is simple and easy, catalyst is stable and easy to make. Synthesis method of the invention in the medical, chemical, pesticide and textile and other fields of important significance. (by machine translation)
One-pot synthesis of 3-arylaminomaleimides from terminal alkynes and isocyanates
Adams, Harry,Baker, Mark,Hodson, Hannah,Morris, Michael J.
, p. 1695 - 1698 (2017/04/06)
The reaction of aryl acetylide anions with phenyl isocyanate and subsequent addition of a protonating agent such as ethanol affords good yields of 3-aminomaleimides, formed by the cyclization of one molecule of alkyne with two isocyanates. When the reaction is quenched with water instead, cyclopentadienone imines are formed as the major products.
One pot synthesis of maleimide and hydantoin by Fe(CO)5 catalyzed [2 + 2 + 1] co-cyclization of acetylene, isocyanate and CO
Mathur, Pradeep,Joshi, Raj Kumar,Rai, Dhirendra Kumar,Jha, Badrinath,Mobin, Shaikh M.
experimental part, p. 5045 - 5054 (2012/06/04)
In the presence of a catalytic amount of Fe(CO)5, terminal acetylenes, isocyanates and CO undergo [2 + 2 + 1] cyclization to form substituted maleimides and hydantoins; when internal alkynes are used, exclusive maleimide formation is observed. While the maleimides can be obtained as the major products, in up to 90% yield, when the reaction is carried out in CO atmosphere, in absence of CO, the hydantoins are formed in up to 87% yield. Formation of maleimides has been shown to occur via the formation of a ferrole intermediate, whereas the hydantoins are proposed to form through successive insertion of isocyanate into the iron-acetylide bond. All compounds were characterized by spectroscopic methods and molecular structures of some compounds were established by single crystal X-ray diffraction method. The Royal Society of Chemistry 2012.
Manganese-catalyzed synthesis of hydantoin derivatives from terminal alkynes and isocyanates
Kuninobu, Yoichiro,Kikuchi, Kou,Takai, Kazuhiko
, p. 740 - 741 (2008/12/21)
Hydantoin derivatives were obtained by the reactions of terminal alkynes with isocyanates in the presence of a catalytic amount of a manganese complex, MnBr(CO)5. This reaction also proceeded using a rhenium complex, Re2(CO)10, or an iron complex, Fe(CO)5, as a catalyst. Copyright
THE REACTIONS OF DIPHENYL- AND PHENYLDIAZOMETHANE WITH IMINOTHIONES
El-Sharief, A. M. Sh.,Ketcham, Roger,Schaumann, Ernst
, p. 83 - 86 (2007/10/02)
Diphenyl- 9 or phenyldiazomethane 10 reacts with 1,3-disubstituted 4-imino-5-thioxo-2-imidazolidinones 1 and 5-imino-2,4-imidazolidinedithiones 2 to replace the 5- or 4-thiocarbonyl group with the diphenyl- 3,4 or the phenylmethylene 5,6 system.Key words: Olefination of the thiocarbonyl group; 1,2-iminothiones; aryldiazomethanes; 1,3-disubstituted imidazolidinetrione derivatives.
