4514-53-8

Usage

Uses

Used in Pharmaceutical Industry:
6-(4-Chlorophenyl)-1,3,5-triazine-2,4-diamine is used as an anticonvulsant medication for the treatment of epilepsy, specifically Lennox-Gastaut syndrome. It is administered orally in the form of tablets or a suspension, providing an effective alternative for patients who do not respond well to other anti-seizure medications.
Used in Clinical Trials and Long-term Patient Care:
Rufinamide is used in clinical trials to establish its effectiveness and safety in treating epilepsy. It has been proven to be a reliable treatment option through long-term use in patients with epilepsy, demonstrating its potential to manage seizure activity and improve the quality of life for those affected by this condition.

InChI:InChI=1/C9H8ClN5/c10-6-3-1-5(2-4-6)7-13-8(11)15-9(12)14-7/h1-4H,(H4,11,12,13,14,15)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 127099-85-8 N-Cyanoguanidine 
• 127099-85-8 dicyandiamide 

Relevant academic research and scientific papers

Carbon and Nitrogen Based Nanosheets as Fluorescent Probes with Tunable Emission

2D carbon and nitrogen based semiconductors (CN) have attracted widespread attention for their possible use as low-cost and environmentally friendly materials for various applications. However, their limited solution-dispersibility and the difficulty in p

Covalent Functionalization of Carbon Nitride Frameworks through Cross-Coupling Reactions

A new and simple synthetic route is introduced to covalently functionalize the carbon nitride (CN) framework by the implementation of halogenated phenyl groups (Cl, Br and I), which serve as a chemically reactive center, within the CN framework. The coval

Green synthesis and self-association of 2,4-diamino-1,3,5-triazine derivatives

2,4-Diamino-1,3,5-triazines have been prepared by reaction of dicyandiamide with nitriles under microwave irradiation, a method that can be considered as a green procedure due to the reduction in the use of solvents during synthesis and purification, the short reaction time and the simplicity of the procedure. The structures have been confirmed in solution by NMR spectroscopy. Variable temperature experiments have been used to calculate the free energy of activation for rotation about the amino-triazine bond. The crystal structures of three 2,4-diamino-6-R-1,3,5-triazine derivatives (3a: R = phenyl, 3i: R = 1-piperidino and 3g: R = 1-phenylpyrazol-3-yl) have been determined by X-ray analysis. The N-H...N interactions change from structure to structure, resulting in a variation from pseudo-honeycomb networks to corrugated rosette layers.

Microwave-assisted clean synthesis of 6-aryl-2,4-diamino-1,3,5-triazines in [bmim][PF6]

An efficient and green approach was developed to prepare 6-aryl-2,4-diamino-1,3,5-triazines from corresponding arylnitriles and dicyanodiamide in ionic liquid [bmim][PF6] under computer-controlled microwave irradiation. Particularly valuable features of this method included the short reaction time, good yield, convenient operation and eco-friendly solvent.

ANTICANCER COMPOSITION AND COMPOUND

An anticancer composition containing a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof. In formula (I), R10 and R20 may be the same or different from each other and each represents hydrogen, halogen, amino, aralkylamino, nitro, lower alkyl, lower alkoxy, lower alkoxyalkoxy, lower aralkyloxy or acyl; R30 and R40 may be the same or different from each other and each represents hydrogen, nicotinoyl, benzoyl or lower alkoxy; and n represents 0 or 1.

Hydroxide-Catalyzed Synthesis of Heterocyclic Aromatic Amine Derivatives from Nitriles

A generalized method for synthesizing a wide variety of heterocyclic aromatic amine derivatives from nitriles by use of hydroxide catalysts is presented.Nitrile dimers (3-aminocrotononitrile and dicyandiamide) and a dimer analog (anthranilonitrile) react with monomeric nitriles in the presence of hydroxide to form respectively, aminopyrimidines, diaminotriazines and aminoquinazolines.