4521-30-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Aminobenzo[b]thiophene is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of drugs with diverse therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Aminobenzo[b]thiophene is utilized as a precursor in the production of agrochemicals, aiding in the creation of compounds with pesticidal or herbicidal properties.
Used in Materials Science:
2-Aminobenzo[b]thiophene is employed as a component in the development of new materials, leveraging its chemical properties to enhance material characteristics such as conductivity or stability.
Used in Drug Development:
As a building block in drug development, 2-Aminobenzo[b]thiophene is used for the creation of novel compounds with potential applications in medicine, underpinning research into new treatments and therapies.

Upstream product

• 66768-64-7 2-Azidobenzothiophene 
• 103317-32-4 (2-bromophenyl)thioacetamide 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 89673-36-9 2-(tert-butoxycarbonylamino)benzothiophene 
• 4521-46-4 1-(chloromethyl)-2-[(phenylmethyl)sulfanyl]benzene 
• 95-15-8 Benzo[b]thiophene 
• 109-89-7 diethylamine 
• 124-40-3 dimethyl amine 
• 4521-44-2 2-(2-(benzylthio)phenyl)acetonitrile 

Downstream Products

• 6278-73-5 2-(4-aminophenyl)benzothiazole 
• 1253038-60-6 C₁₈H₁₁NO₂S 

Relevant academic research and scientific papers

Construction of 2-Arylbenzo[4,5]thieno[2,3-d]thiazole Skeleton via CuCl/S-Mediated Three-Component Reaction

An exclusive thiophene-fused polycyclic I-conjugated 2-arylbenzo[4,5]thieno[2,3-d]thiazole skeleton was constructed via a one-pot CuCl-mediated three-component reaction, using 2-(2-bromophenyl)acetonitrile and aromatic aldehydes as substrates and elementa

Direct synthesis of diverse 2-aminobenzo[b]thiophenes via palladium-catalyzed carbon-sulfur bond formation using Na2S2O3 as the sulfur source

A novel and direct synthesis of various 2-aminobenzo[b]thiophenes has been developed. The reactions were catalyzed by a combination of Pd(dppf)Cl2 and dppf using odorless and cheap Na2S2O3 as the sulfur source. This strategy allowed us to synthesize important 2-aminobenzo[b]thiophene scaffold more efficiently and conveniently.

Methods for inhibiting protein kinases

The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

Imidazopyrazines as protein kinase inhibitors

In its many embodiments, the present invention provides a novel class of imidazopyrazine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions.

General preparation of primary, secondary, and tertiary aryl amines by the oxidative coupling of polyfunctional aryl and heteroaryl amidocuprates

(Chemical Equation Presented). A tolerant reaction: Functionalized tertiary amines have been prepared by the oxidative coupling of amidocuprates with chloranil used as the oxidant (see Scheme). A high tolerance of functional groups and insensitivity to steric hindrance characterize this general amination reaction.

REVERSED PYRIMIDINONE COMPOUNDS AS CALCILYTICS

Calcilytic compounds and methods of preparing them are disclosed. Methods of using the calcilytic compounds are also provided.

Electrophilic Amination of Higher Order Cuprates with N,O-Bis(trimethylsilyl)hydroxylamine

In the reaction of higher order cyanocuprates with N,O-bis(trimethylsilyl)hydroxylamine delivery of the NHSiMe3 moiety to one of the anionic ligands in the cuprate takes place even in the absence of external bases according to an "electrophilic amination" protocol.Details of the methodology are given, and the reaction mechanism is analyzed in terms of interception by a mixed bis-metal cluster of a lithium N-silyl-N-siloxyamide, followed by intramolecular C-N coupling.This method is applicable to cyanocuprates bearing aromatic, heteroaromatic, and saturated aliphatic ligands.A number of 2-amino-substituted heterocycles, not easily accesible by normal routes, can be obtained with the aid of a stabilizing silylation at the nitrogen atom.

THERMAL REACTIVITY OF 2-AZIDO- AND 3-AZIDO-BENZOTHIOPHENE WITH DIALKYLAMINES AND ALKANETHIOLS

On thermolysis in diethyl- or dimethyl-amine both 3-azido- and 2-azidobenzothiophene afford the appopriate 3-(dialkylamino)-2-aminobenzothiophene in good yield, whereas in ethyl or butyl mercaptan at room temperature, these azides smoothly lead to 2-(alkylthio)-3-amino- and 3-(alkylthio)-2-amino-benzothiophene, respectively.