4521-30-6

Basic information

• Product Name: 2-Aminobenzo[b]thiophene
• Synonyms: 2-Aminobenzo[b]thiophene
• CAS NO: 4521-30-6
• Molecular Formula: C₈H₇NS
• Molecular Weight: 149.22
• Mol File: 4521-30-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 115-117 °C
• Boiling Point: 313.15 °C at 760 mmHg
• Flash Point: 143.188 °C
• Appearance: /
• Density: 1.294 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.79±0.10(Predicted)
• CAS DataBase Reference: 2-Aminobenzo[b]thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Aminobenzo[b]thiophene(4521-30-6)
• EPA Substance Registry System: 2-Aminobenzo[b]thiophene(4521-30-6)

Safety Data

• Hazardous Substances Data: 4521-30-6(Hazardous Substances Data)

Usage

General Description

2-Aminobenzo[b]thiophene is a chemical compound with the molecular formula C8H7NS. It consists of a benzene ring fused to a thiophene ring, with an amino group attached to the benzene ring at the 2 position. The compound is a yellowish-brown solid at room temperature and is insoluble in water but soluble in organic solvents. It is used in the synthesis of various pharmaceuticals, agrochemicals, and materials due to its versatile reactivity and pharmacological properties. 2-Aminobenzo[b]thiophene is also known for its potential as a building block in the development of new drugs and materials with diverse biological activities and applications.

Upstream product

• 103317-32-4 (2-bromophenyl)thioacetamide 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 89673-36-9 2-(tert-butoxycarbonylamino)benzothiophene 
• 4521-46-4 1-(chloromethyl)-2-[(phenylmethyl)sulfanyl]benzene 
• 66768-64-7 2-Azidobenzothiophene 
• 95-15-8 Benzo[b]thiophene 
• 109-89-7 diethylamine 
• 124-40-3 dimethyl amine 
• 4521-44-2 2-(2-(benzylthio)phenyl)acetonitrile 

Downstream Products

• 1253038-60-6 C₁₈H₁₁NO₂S 
• 6278-73-5 2-(4-aminophenyl)benzothiazole 

Relevant articles and documents

Construction of 2-Arylbenzo[4,5]thieno[2,3-d]thiazole Skeleton via CuCl/S-Mediated Three-Component Reaction

An exclusive thiophene-fused polycyclic I-conjugated 2-arylbenzo[4,5]thieno[2,3-d]thiazole skeleton was constructed via a one-pot CuCl-mediated three-component reaction, using 2-(2-bromophenyl)acetonitrile and aromatic aldehydes as substrates and elementa

Methods for inhibiting protein kinases

The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim-1 kinase, and tyrosine kinase using imidazo[1,2-a]pyrazine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.

General preparation of primary, secondary, and tertiary aryl amines by the oxidative coupling of polyfunctional aryl and heteroaryl amidocuprates

(Chemical Equation Presented). A tolerant reaction: Functionalized tertiary amines have been prepared by the oxidative coupling of amidocuprates with chloranil used as the oxidant (see Scheme). A high tolerance of functional groups and insensitivity to steric hindrance characterize this general amination reaction.