452307-58-3

Upstream product

• 452307-55-0 4'-methoxy-2',6'-dimethyl-2-(4-methoxybenzoyl)biphenyl-4-carbonitrile 
• 452307-54-9 acetic acid, 2-bromo-1-(4-methoxy-2,6-dimethylphenyl)-3-(4-methoxyphenyl)-3-oxopropyl ester 
• 452307-53-8 2,3-dibromo-3-(4-methoxy-2,6-dimethylphenyl)-1-(4-methoxyphenyl)propan-1-one 
• 452307-52-7 3-(4-methoxy-2,6-dimethylphenyl)-1-(4-methoxyphenyl)propynone 
• 19447-00-8 4-methoxy-2,6-dimethylbenzylaldehyde 
• 874-63-5 3,5-dimethylmethoxybenzene 
• 452307-56-1 4'-methoxy-6'-methyl-2'-bromomethyl-2-(4-methoxybenzoyl)biphenyl-4-carbonitrile 

Downstream Products

• 452307-63-0 1-[7-hydroxy-10-(4-hydroxyphenyl)-5-methylphenanthren-2-yl]ethanone 
• 452307-60-7 1-[7-hydroxy-10-(4-hydroxyphenyl)-5-methylphenanthren-2-yl]propan-1-one 
• 452307-44-7 1-[7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl]-ethanone 
• 452307-42-5 1-{7-hydroxy-5-methyl-10-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-phenanthren-2-yl}-2-methyl-propan-1-one 
• 524740-44-1 7-(1-hydroxy-1-methylethyl)-4-methyl-9-[4-(2-(piperidin-1-yl)ethoxy)phenyl]phenanthren-2-ol 
• 524740-45-2 7-(1-hydroxy-1,2-dimethylpropyl)-4-methyl-9-[4-(2-(piperidin-1-yl)ethoxy)phenyl]phenanthren-2-ol 
• 452307-62-9 1-[7-methoxy-10-(4-methoxyphenyl)-5-methylphenanthren-2-yl]ethanone 

Relevant academic research and scientific papers

De novo design, synthesis, and evaluation of novel nonsteroidal phenanthrene ligands for the estrogen receptor

Although there are many estrogen receptor antagonists with improved tissue selectivity profiles compared with tamoxifen, optimal tissue selectivity has not yet been demonstrated. As such there is still a need for additional diversity and new chemical scaf

Non-steroidal estrogen receptor ligands

Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor related disease states. The compounds specified are tetra-cyc