452921-82-3Relevant articles and documents
Synthesis and biological evaluation of novel analogues and prodrugs of the cytotoxic antibiotic CC-1065 for selective cancer therapy
Tietze, Lutz F.,Herzig, Tobias,Feuerstein, Tim,Schuberth, Ingrid
, p. 1634 - 1645 (2007/10/03)
This paper describes novel seco-analogues 25-27 of the cytotoxic antibiotic CC-1065 (1) and their prodrugs 5, 6a, and 6b, for antibody-directed enzyme prodrug therapy (ADEPT). The partially hydrogenated seco-CCI-analogue 7 and the corresponding methyl-CCI