4535-07-3

Upstream product

• 39199-63-8 4-nitroindan-1,3-dione-2-carboxylic acid ethyl ester 
• 641-70-3 3-nitrophthalic acid anhydride 
• 1215220-51-1 1,1,3-tribromo-4-nitro-2,3-dihydro-1H-indene 
• 141-97-9 ethyl acetoacetate 
• 603-11-2 3-nitrophthalic acid 

Downstream Products

• 352000-78-3 7-amino-3-hydroxy-indan-1-one 
• 80960-26-5 2,2-dihydroxy-4-nitro-1H-indene-1,3(2H)-dione 

Relevant academic research and scientific papers

One-step synthesis of substituted isobenzofuran-1(3H)-ones and isobenzofuran-1,3-diones from indane derivatives in subcritical media

Molecular oxygen is one of the most attractive oxidants in organic synthesis because it is highly soluble in subcritical water. In this study, indane derivatives were oxidized to the corresponding isobenzofuran-1(3H)-one with molecular oxygen and isobenzofuran-1,3-dione with a mixture of molecular oxygen and H2O2 in subcritical water. This paper describes a simple, economic, environmentally benign,and general procedure that can be used for the synthesis of substituted isobenzofuran-1(3H)-ones and isobenzofuran-1,3-diones in only one step and without catalyst.

ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS

This disclosure provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS

The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

Cyclopropanation of active methylene compounds with β-alkoxycarbonyl vinylsulfonium salts

An efficient synthesis of β-alkoxycarbonyl vinylsulfonium salts had been developed. Their reaction with indene-1,3-diones and other active methylene compounds provided cyclopropane carboxylates in good yields. A tentative reaction mechanism was proposed.

Efficient synthesis of 7-amino-3-hydroxyindan-1-one

An efficient and reliable three-step synthesis of 7-amino-3-hydroxyindan-1- one (7) is described. Compound 7 is a versatile, three-dimensional, three-point scaffold that is useful for the construction of focused compound libraries. Copyright Taylor & Fran

Lanthanide triflate catalyzed 1,3-dipolar cycloaddition reactions: Stereoselective synthesis of indenoisoxazolidines

Substituted indenones reacted smoothly with a variety of in situ generated nitrones in the presence of lanthanide triflates to give exclusive exo 1,3-dipolar cycloaddition products in high yield. Judicious choice of the nitrone substituents allowed for further modification of the indenoisoxazolidine core to the corresponding indenoisoxazoline and indenoisoxazole analogs in high yield.

Spiroconjugated charge-transfer dyes for optical applications

New intramolecular charge-transfer organic dyes are described. The design of these molecules is based on the phenomenon of spiroconjugation, and it provides a modular approach to the preparation of unique materials with interesting optical properties. In the dyes of the invention, the lowest unoccupied molecular orbital (LUMO) of the acceptor part (based on indandione) is spiroconjugated with the highest unoccupied molecular orbital (HOMO) of the donor part (amines, alcohols and thiols). The interaction between the donor and acceptor is controlled by the energy and symmetry of the frontier orbitals. The novel dyes described herein, with predictable and tunable optical properties, can be used in many optical applications including nonlinear optics (NLO).