80960-26-5

Upstream product

• 4535-07-3 4-nitro-2,3-dihydro-1H-indene-1,3-dione 
• 24623-25-4 4-nitro-2,3-dihydro-1H-inden-1-one 
• 603-11-2 3-nitrophthalic acid 
• 641-70-3 3-nitrophthalic acid anhydride 
• 39199-63-8 4-nitroindan-1,3-dione-2-carboxylic acid ethyl ester 

Downstream Products

• 1416232-06-8 1-(benzylamino)-4b,9b-dihydroxy-7-isopropyl-4bH-indeno[1,2-b]benzofuran-10(9bH)-one 
• 1416258-22-4 4-amino-2-hydroxy-2-(4-isopropyl-2-methoxyphenyl)-2H-inden-1,3-dione 
• 1416258-20-2 2-azido-2-(4-isopropyl-2-methoxyphenyl)-4-nitro-2H-inden-1,3-dione 
• 1416258-19-9 2-chloro-2-(4-isopropyl-2-methoxyphenyl)-4-nitro-2H-inden-1,3-dione 

Relevant academic research and scientific papers

ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS

This disclosure provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS

The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.

Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion

Ninhydrins show extensive application in organic chemistry and agriculture whereas they have been poorly investigated as bioactive molecules for medicinal chemistry purposes. A series of ninhydrin derivatives was here investigated for the inhibition of human carbonic anhydrases (CAs, EC 4.2.1.1), based on earlier evidence that gem diols are able to coordinate the metal ion from the CA active site. Ninhydrins demonstrated a micromolar inhibitory action against CA I and IX (KIs in the range 0.57–68.2 μM) and up to a nanomolar efficacy against CA II and VII (KIs in the range 0.025–78.2 μM), validated isoforms as targets in several CNS-related diseases. CA IV was instead weakly or poorly inhibited. A computational protocol based on docking, MM-GBSA and metadynamics calculations was used to elucidate the putative binding mode of this type of inhibitors to CA II and CA VII. The findings of this study testify that such pharmacologically underestimated ligands may represent interesting lead compounds for the development of CA inhibitors possessing an innovative mechanism of action, i.e., mono- or bis-coordination to the zinc ion through the diol moiety.

Microwave-assisted oxidation of indan-1-ones into ninhydrins

A simple and general microwave-assisted selenium oxidation has been developed for the synthesis of substituted ninhydrins from indan-1-ones in order to access to indeno[1,2-b]indoles substituted on the A ring. This efficient and convenient oxidation, using selenium dioxide under microwave irradiations, afforded mono- and di-substituted ninhydrins in a single step reaction with good yields.

1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT

The present invention relates to 1,3-dioxoindene derivatives, pharmaceutically acceptable salts or optical isomers thereof, a preparation method for same, and a pharmaceutical composition containing same as an active ingredient with antiviral activity. Th

1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT

Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredi

IODONIUM DERIVATIVES OF β-DIKETONES. XX. NEW METHOD FOR THE PRODUCTION OF PHENYLIODONIUM BETAINES OF 1,3-INDANEDIONES AND THEIR CLEAVAGE BY NITRIC ACID. USE OF THE CLEAVAGE OF PHENYLIODONIUM BETAINES FOR THE PRODUCTION OF 1,2,3-TRICARBONYL COMPOUNDS

The reaction of 1,3-indanediones and its derivatives substituted in the phthaloyl ring with (diacetoxyiodo)benzene in a mixture of chloroform, ethanol, and diethyl ether at 7-12 deg C gives the corresponding phenyliodonium betaines with good yields.Cleavage of the phenyliodonium betaines of β-dicarbonyl compounds by nitric acid leads to the hydrates of the 1,2,3-tricarbonyl compounds.The reaction is limited by the high CH acidity of the β-dicarbonyl compound.