454-73-9

Usage

Uses

Used in Pharmaceutical Industry:
3-Fluoro-5-nitrobenzotrifluoride is used as a key intermediate in the synthesis of androgen receptor modulators and other pharmaceutical compounds. Its unique structure and reactivity allow for the development of novel drugs with potential therapeutic applications in various medical conditions.
Used in Organic Synthesis:
3-Fluoro-5-nitrobenzotrifluoride serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications. Its tri-substituted benzene core can be further modified and functionalized to produce various organic molecules for use in different industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
As a tri-substituted benzene derivative, 3-Fluoro-5-nitrobenzotrifluoride is also utilized in research and development settings to explore its chemical properties, reactivity, and potential applications. This can lead to the discovery of new synthetic routes, reaction mechanisms, and innovative uses for 3-FLUORO-5-NITROBENZOTRIFLUORIDE in various fields.

Upstream product

• 3819-88-3 1-fluoro-3-iodo-5-nitrobenzene 
• 393-75-9 4-chloro-3,5-dinitrobenzotrifluoride 
• 401-99-0 3,5-dinitrobenzotrifluoride 

Downstream Products

• 401-99-0 3,5-dinitrobenzotrifluoride 
• 133532-73-7 3,5'-dinitro-5,5'-bis-trifluoromethyldiphenyl ether 
• 1107062-37-2 1-(4-(methylsulfonyl)phenoxy)-3-nitro-5-(trifluoromethyl)benzene 
• 454-67-1 3-fluoro-5-trifluoromethylaniline 
• 402-02-8 acetic acid-(3-fluoro-5-trifluoromethyl-anilide) 

Relevant academic research and scientific papers

UREA AND BIS-UREA BASED COMPOUNDS AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF ANDROGEN RECEPTOR MEDIATED DISEASES OR DISORDERS

Urea-based and bis-urea based compounds and analogues thereof are disclosed. These compounds are useful in the treatment of androgen-dependent diseases or disorders and androgen receptor-mediated diseases or disorders. Specifically, the compounds are useful in the treatment of diseases or disorders that are AR negative.

PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS

Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.

Antibacterial agents

Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.

Nucleophilic Substitution of Nitro Group in 3,5-Dinitrobenzotrifluoride

In the reaction of 3,5-dinitrobenzotrifluoride with phenols and thiophenol in the presence of potassium carbonate, fluoride- and nitrite-ions in DMF at 25-145°C, substitution of a nitro group takes place with formation of the corresponding 3-nitro-5-R-benzotrifluorides.