454-73-9

Basic information

• Product Name: 3-FLUORO-5-NITROBENZOTRIFLUORIDE
• Synonyms: 3-FLUORO-5-NITRO-1-TRIFLUOROMETHYLBENZENE;3-FLUORO-5-NITROBENZOTRIFLUORIDE;3-Fluoro-5-(trifluoromethyl)nitrobenzene;3-FLUORO-5-NITRO-1-TRIFLUOROMETHYLBENZENE 98%;3-fluoro-5-nitrobenzotrifluoride 3-Fluoro-5-(trifluoromethyl)nitrobenzene;3-Fuoro-5-nitrobenzotrifluoride;1-Fluoro-3-nitro-5-(trifluoroMethyl)benzene;Benzene, 1-fluoro-3-nitro-5-(trifluoroMethyl)-
• CAS NO: 454-73-9
• Molecular Formula: C₇H₃F₄NO₂
• Molecular Weight: 209.1
• Product Categories: Fluorine series
• Mol File: 454-73-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 186.028 °C at 760 mmHg
• Flash Point: 66.308 °C
• Appearance: /
• Density: 1.504 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 3-FLUORO-5-NITROBENZOTRIFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-5-NITROBENZOTRIFLUORIDE(454-73-9)
• EPA Substance Registry System: 3-FLUORO-5-NITROBENZOTRIFLUORIDE(454-73-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 454-73-9(Hazardous Substances Data)

Usage

Uses

3-Fluoro-5-nitrobenzotrifluoride, is a tri-substitiuted benzene derivative used in the preparation of androgen receptor modulators and other pharmaceutical compounds.

Upstream product

• 401-99-0 3,5-dinitrobenzotrifluoride 
• 3819-88-3 1-fluoro-3-iodo-5-nitrobenzene 
• 393-75-9 4-chloro-3,5-dinitrobenzotrifluoride 

Downstream Products

• 1613588-49-0 [3-[4-[[3-[5-[(N,N'-bis(tert-butoxycarbonyl)carbamimidoyl)amino]pentanoylamino]-2-[2-(tert-butoxycarbonylamino)ethylsulfanyl]-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-5-(trifluoromethyl)phenyl]azinic acid 
• 1613588-51-4 C₃₉H₄₈F₆N₈O₇S 
• 1613588-62-7 C₅₁H₆₉F₆N₉O₁₁S 
• 1613588-47-8 (4-(2-(2-aminoethylthio)-3-(3-(4-(3-(trifluoromethyl)-5-nitrophenoxy)phenyl)ureido)-5-(trifluoromethyl)phenylcarbamoyl)butyl)guanidine 
• 1613588-57-0 tert-butyl N-[N-[5-[[3-[[4-[3-amino-5-(trifluoromethyl)phenoxy]phenyl]carbamoylamino]-2-[2-(tert-butoxycarbonylamino)ethylsulfanyl]-5-(trifluoromethyl)phenyl]amino]-5-oxopentyl]-N'-tert-butoxycarbonylcarbamimidoyl]carbamate 
• 1613588-56-9 (4-(2-(2-aminoethylthio)-3-(3-(4-(3-amino-5-(trifluoromethyl)phenoxy)phenyl)ureido)-5-(trifluoromethyl)phenylcarbamoyl)butyl)guanidine 
• 1613588-61-6 (4-(2-(2-aminoethylthio)-3-(3-(4-(3-(2-aminoethylamino)-5-(trifluoromethyl)phenoxy)phenyl)ureido)-5-(trifluoromethyl)phenylcarbamoyl)butyl)guanidine 
• 1107062-37-2 1-(4-(methylsulfonyl)phenoxy)-3-nitro-5-(trifluoromethyl)benzene 
• 402-02-8 acetic acid-(3-fluoro-5-trifluoromethyl-anilide) 

Relevant articles and documents

UREA AND BIS-UREA BASED COMPOUNDS AND ANALOGUES THEREOF USEFUL IN THE TREATMENT OF ANDROGEN RECEPTOR MEDIATED DISEASES OR DISORDERS

Urea-based and bis-urea based compounds and analogues thereof are disclosed. These compounds are useful in the treatment of androgen-dependent diseases or disorders and androgen receptor-mediated diseases or disorders. Specifically, the compounds are useful in the treatment of diseases or disorders that are AR negative.

Antibacterial agents

Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.

Nucleophilic Substitution of Nitro Group in 3,5-Dinitrobenzotrifluoride

In the reaction of 3,5-dinitrobenzotrifluoride with phenols and thiophenol in the presence of potassium carbonate, fluoride- and nitrite-ions in DMF at 25-145°C, substitution of a nitro group takes place with formation of the corresponding 3-nitro-5-R-benzotrifluorides.