4545-84-0

Upstream product

• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 1165952-91-9 cyclohexa-1,3-diene 
• 186581-53-3 diazomethane 
• 24327-08-0 meso-endo-tetrahydro-4,7-ethanoisobenzofuran-1,3-dione 
• 67-56-1 methanol 
• 28871-80-9 bicyclo<2.2.2>oct-5-ene 2,3-endo,exo-dicarboxylic acid 
• 56787-64-5 bicyclo<2.2.2>oct-5-ene-trans-2,3-dicarboxylic acid exo-3-methyl ester 
• 84258-03-7 trans-Bicyclo<2.2.2>octen-(5)-2,3-dicarboxychlorid 
• 84258-03-7 trans-2,3-bis(chloroformyl)bicyclo<2.2.2>oct-5-ene 
• 624-49-7 dimethylfumarate 

Downstream Products

• 67367-21-9 3-benzoyl-(3ac,7ac)-3a,4,5,6,7,7a-hexahydro-4r,7c-ethano-benzo[d]isoxazole-5t,6t-dicarboxylic acid dimethyl ester 
• 67367-21-9 3-benzoyl-(3at,7at)-3a,4,5,6,7,7a-hexahydro-4r,7c-ethano-benzo[d]isoxazole-5t,6t-dicarboxylic acid dimethyl ester 
• 72443-96-0 methyl (2SR,10RS)-2-(phenylseleno)-4-oxa-5-oxotricyclo<4.3.1.0^3,7>decane-10-carboxylate 
• 72443-95-9 methyl (2SR,7RS)-2-(phenylseleno)-4-oxa-5-oxotricyclo<4.4.0.0^3,8>decane-7-carboxylate 
• 72443-97-1 dimethyl (2SR,3RS,5SR,6RS)-2-(phenylseleno)-3-chloro-bicyclo<2.2.2>octane-5,6-dicarboxylate 
• 72496-17-4 dimethyl (2SR,3SR,5SR,6RS)-2-(phenylseleno)-3-chlorobicyclo<2.2.2>octane-5,6-dicarboxylate 
• 72444-14-5 methyl (2SR,10RS)-2-<(4-methoxy-2-nitrophenyl)thio>-4-oxatricyclo<4.3.1.0^3,7>deca-5-one-10-carboxylate 
• 72444-09-8 methyl (2SR,7RS)-2-<(4-methoxy-2-nitrophenyl)thio>-4-oxa-5-oxotricyclo<4.4.0.0^3,8>decane-7-carboxylate 
• 72444-05-4 methyl (2SR,7RS)-2-<(4-methoxyphenyl)thio>-4-oxa-5-oxotricyclo<4.4.0.0^3,8>decane-7-carboxylate 
• 72444-11-2 methyl (2SR,10RS)-2-<(4-chloro-2-nitrophenyl)thio>-4-oxatricyclo<4.3.1.0^3,7>deca-5-one-10-carboxylate 
• 72444-06-5 methyl (2SR,7RS)-2-<(4-chloro-2-nitrophenyl)thio>-4-oxa-5-oxotricyclo<4.4.0.0^3,8>decane-7-carboxylate 
• 72444-15-6 methyl (2SR,10RS)-2-<(2-methyl-4-nitrophenyl)thio>-4-oxatricyclo<4.3.1.0^3,7>deca-5-one-10-carboxylate 
• 72453-32-8 methyl (2SR,7RS)-2-<(2-methyl-4-nitrophenyl)thio>-4-oxa-5-oxotricyclo<4.4.0.0^3,8>decane-7-carboxylate 
• 4545-84-0 dimethyl bicyclo<2,2,2>oct-5-ene-endo-2,exo-3-dicarboxylate 

Relevant academic research and scientific papers

Enzymatic optical resolution of norbornanecarboxylic esters using Pig Liver Esterase

The hydrolysis of a series of norbornane-type carboxylic esters catalyzed by pig liver esterase (PLE) has been investigated.It was found that an exo-ester function (syn to the C7 methylene group) is hydrolyzed with high preference.Enantioselective hydrolysis can be accomplished when a vicinal carbonyl-containing function (ester, formyl, acetyl) is present in a trans position with respect to the exo ester.The regiospecifity of the enzymatic hydrolysis has been used for the separation of exo/endo mixtures of the cycloadducts derived from cyclopentadiene and alkene esters.The regiospecifity and enantioselectivity of the enzymatic hydrolysis of norbornane-type esters were analyzed in terms of Tamm's substrate model and also by Griengl's method.

Deuterium Kinetic Isotope Effects in the 1,4-Dimethylenecyclohexane Boat Cope Rearrangement

In order to examine the extent of bond making in the boat-like 3,3-sigmatropic shift transition states, trans-2,3-dimethyl-1,4-dimethylenecyclohexane (T) and its exomethylene tetradeuteria derivative (TXD) were prepared.The 3,3-shift of TXD at 305 deg C r

Derivatives of Bicyclooctane-2,6:3,5-dicarbolactone

The reactions of the title dilactone with both acid and base are discussed.Evidence is presented for stable γ-lactones in the bicyclooctane-2,6-carbolactone series.Epimerization α to hindered acid groups occurs under acetylating conditions to relieve steric strain in this system.

Additions of Group 6A and 7A Electrophilic Reagents to Dimethyl endo,endo-Bicyclooct-5-ene-2,3-dicarboxylate: Competitive Formation of γ- and δ-Lactones

The reaction of dimethyl endo,endo-bicyclooct-5-ene-2,3-dicarboxylate with chlorine, bromine, iodine, benzeneselenenyl chloride, and benzenesulphenyl chloride has been studied.Under conditions of kinetic control both γ- and δ-lactones are formed, the δ lactone being predominant except in the case of bromine.The thermodynamic product distributions favored the δ-lactone exclusively.A general mechanistic scheme is proposed.

Electrophilic additions to strained alkenes. II. The reaction of benzeneselenenyl chloride with tricyclo2,5>deca-3,7-diene derivatives

The reactions of benzeneselenenyl chloride with three derivatives of tricyclo2,5>deca-3,7-diene have been investigated in four solvent systems: methylene chloride, acetic acid, acetic acid/LiClO4, and methanol.Under conditions of kinetic control only products of exo-anti attack upon the cyclobutene moiety are isolable when the solvent system is methylene chloride or acetic aicd.This observation also holds in acetic acid/LiClO4 except in the case of dimethyl tricyclo2,5>deca-3,7,9-triene-7,8-dicarboxylate where the major product is that of cross-bonding with solvent incorporation.In methanol products of solvent incorporation, transannular cross-bonding and lactonization (where possible) are observed.A general mechanistic scheme is proposed to account for these observations in accord with earlier results for the analogous arenesulphenylations.