4546-06-9

Upstream product

• 4546-04-7 tetraethyl 1,4-xylylenediphosphonate 
• 52577-04-5 p-xylylene-α,α'-bis(phosphonic acid dimethyl ester) 
• 623-24-5 1,4-bis(bromomethyl)benzene 
• 623-25-6 p-Xylylene dichloride 
• 122-52-1 triethyl phosphite 
• 589-29-7 p-xylylene glycol 

Relevant academic research and scientific papers

Structural diversity of lanthanum-organic frameworks based on 1,4-phenylenebis(methylene)diphosphonic acid

The preparation of five different compounds, [La2(H 2pmd)3(H2O)12] (1: 1D), [La 2(H2pmd)(pmd)(H2O)2] (2: 3D), [La(H3pmd)(H2pmd)(H

Organic-inorganic hybrid porous sulfonated zinc phosphonate material: Efficient catalyst for biodiesel synthesis at room temperature

A new porous zinc phosphonate material (HZnP-1) has been synthesized via the reaction between p-xylenediphosphonic acid and anhydrous ZnCl2 under hydrothermal and mildly acidic conditions (pH ～ 5) in the absence of any structure directing agent. The phenyl group of this material has been sulfonated with concentrated sulfuric acid to obtain sulfonic acid functionalized material HZnPS-1. Powder X-ray diffraction (XRD), field emission scanning electron microscopy (FE SEM), N2 sorption, solid state 13C CP MAS and 31P MAS NMR, and FT IR spectroscopic tools are employed to characterize these materials. The crystal structures of both the materials are indexed corresponding to the new orthorhombic phases with unit cell parameters a = 11.00, b = 8.74, c = 14.62 A, α = β = γ = 90° for HZnP-1, and a = 10.65, b = 13.52, c = 15.30 A and α = β = γ = 90° for HZnPS-1. HZnPS-1 showed outstanding catalytic activity and high recycling efficiency for the synthesis of different biodiesel compounds via esterification of long chain fatty acids by using methanol as both reactant and solvent at room temperature. The green and eco-friendly catalytic system described herein can overcome the problem faced by the existing catalytic systems known in biodiesel synthesis, such as drastic conditions (high reaction temperature) and requirement of hazardous organic solvents.

Rapid one-pot synthesis of alkane-α ω, diylbisphosphonic acids from dihalogenoalkanes under microwave irradiation

A one-pot, two-step synthesis of alkylenebisphosphonic acids from dihalogenoalkanes was performed under microwave irradiation. The reaction is very rapid and convenient for the synthesis of small samples of alkylenebisphosphonic acids. Copyright Taylor & Francis Group, LLC.

Hybrid cyclic dimers of divacant heteropolyanions: Synthesis, mass spectrometry (MALDI-TOF and ESI-MS) and NMR multinuclear characterisation

In the field of organic-inorganic hybrid composites, functionalized polyoxometalates constitute a special class of inorganic nanobuilding blocks (NBBs). This study represents a first approach related to the formation of new oligomeric hybrid species based on the reaction of bis(electrophilic) groups with a divacant heteropolyanion as the NBB. Bis(phosphonates) such as para-H2O3PCH2(C6H4) nCH2PO3H2 (n = 1 or 2) have been treated with the divacant heteropolyanion [γ-SiW10O 36]8- to form the hybrid cyclic dimer [H 2((SiW10O36) (O=PCH2(C 6H4)nCH2P=O)]2] 6-. MALDI-TOF and ESI mass spectrometry have been used as essential analytical techniques for the characterization of such composite systems. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

The synthesis of novel bisphosphonates as inhibitors of phosphoglycerate kinase (3-PGK)

A series of conformationally-restrained analogues of 1,3-bisphospho-D-glyceric acid (1,3-BPG) 1 has been synthesised for use as inhibitors of 3-PGK (E.C. 2.7.2.3). These compounds have non-scissile phosphonate linkages and also incorporate α-halogen substituents to make them isopolar and isosteric mimics of the natural substrate. A monocyclic aryl core between the two phosphoryl centres provides both a rigid framework linking these moieties and loci for further substitution. The compounds were tested against human 3-PGK and found to be good competitive inhibitors. α-Fluorination of the phosphonic acids increased the affinity for the enzyme into the submicromolar range. Correlation of IC50 data with pKa. and pKa, values indicates that the acidity of the phosphoryl group exerts a strong influence on protein binding. The Royal Society of Chemistry 2000.

Phosphonic acid derivatives useful as anti-inflammatory agents

Novel acids, esters, and salts of phenyl, naphthyl, quinoxalinyl, and biphenyl bisphosphonic acids and 1,2-oxaphosphepins are described. These compounds are useful as antiinflammatory and anti-arthritic agents. Also described are known compounds of the phenyl, naphthyl, quinoxalinyl, and biphenyl bisphosphonate classes which are also useful as antiinflammatory and anti-arthritic agents. Representative compounds include [1,2-phenyldiyl]bis (methylene)bisphosphonic acid tetramethyl ester, [2,3-quinoxalindiyl]bis(methylene)bisphosphonic acid tetramethyl ester, [[3-(propyl)-4-(methoxy)-1,8-naphthalenediyl]bis(methylene)]bisphosphonic acid tetramethyl ester, [2,6-naphthalenediylbis(methylene) bisphosphonic acid tetraethyl ester, and [2,2'-biphenylenebis(methyl)]bisphosphonic acid tetramethyl ester. Representative oxaphosphepins include the preferred 3,4-dihydro-3-methoxy -7-(phenylmethoxy)-1H-naphth[1,8de][1,2]oxaphosphepin-3-oxide.

Phosphonic acid derivatives useful as anti-inflammatory agents

Novel 1,2-oxaphosphepins are useful as antiinflammatory and antiarthritic agents. A representative oxaphosphepin is 3,4-dihydro-3-methoxy-7-(phenylmethoxy)-1H-naphth[1,8de][1,2]oxaphosphepin-3-oxide.

(o-Hydroxyphenyl)methylphosphonic acids: Synthesis and Potentiometric Determinations of their pKa Values

(o-Hydroxyphenyl)methylphosphonic acids are readily obtained from o-(bromomethyl)- or o-(hydroxymethyl)phenols and trialkyl phosphites.Subsequent hydrolysis leads to the corresponding phosphonic acids.For a series of such compounds, the pKa val