45467-31-0Relevant academic research and scientific papers
Preparation of nitramine-nitrates by ring-opening nitration of azetidines by dinitrogen pentoxide (N2O5)
Golding, Peter,Millar, Ross W.,Paul, Norman C.,Richards, David H.
, p. 5073 - 5082 (2007/10/02)
Eleven azetidines, bearing various types of substituents on the ring nitrogen, were treated with N2O5 in chlorinated solvents at sub-ambient temperature and in certain cases formed 1,3-nitramine-nitrate products by a novel rig-openin
Efficient synthesis of azetidine through N-trityl- or N- dimethoxytritylazetidines starting from 3-amino-1-propanol or 3- halopropylamine hydrohalides
Huszthy,Bradshaw,Krakowiak,Wang,Dalley
, p. 1197 - 1207 (2007/10/02)
Efficient synthetic routes for the preparation of azetidine starting from commercially available 3-amino-1-propanol or 3-halopropylamine hydrohalides are reported. First, the appropriate N-trityl- or N-dimethoxytrityl protected tosyloxy- or halopropylamines were prepared. These precursors were then cyclized into the N-trityl- or N-dimethoxytritylazetidines. The N-protecting groups were removed in the presence of perchloric acid giving the hydrogen perchlorate salt of azetidine. The latter compound was transformed into its free base using a strong base under anhydrous conditions. The relatively expensive 4,4'-dimethoxytrityl chloride and less expensive trityl chloride used in these synthetic procedures were recycled in good yields. Azetidine hydrogenperchlorate can be used to prepare N-substituted azetidines without the need to isolate the free azetidine.
Substituted dibenzothiophenes
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, (2008/06/13)
This disclosure described novel derivatives of dibenzothiophene, dibenzothiophene sulfoxide, dibenzothiophene sulfone, thioxanthene, thioxanthene sulfoxide and thioxanthene sulfone which are active as modulators of the mammalian immune response system.
