454701-66-7 Usage
Uses
Used in Organic Synthesis:
N-Boc-3-thioMorpholinopropylaMine is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable component in the creation of complex organic molecules with potential applications in the pharmaceutical industry.
Used in Pharmaceutical Research:
N-Boc-3-thioMorpholinopropylaMine is used as a reagent in organic reactions, facilitating the development of new chemical entities with therapeutic applications. Its versatility and functional groups enable the synthesis of novel compounds with potential benefits in the treatment of various diseases and conditions.
Used in Drug Development:
In the pharmaceutical industry, N-Boc-3-thioMorpholinopropylaMine is used as a key intermediate in the synthesis of drug candidates. Its structural and functional properties allow for the design and development of innovative drugs with improved efficacy, safety, and pharmacokinetic profiles.
Used in Medicinal Chemistry:
N-Boc-3-thioMorpholinopropylaMine is employed as a versatile tool in medicinal chemistry, enabling researchers to explore the structure-activity relationships of potential drug candidates. Its unique features and reactivity contribute to the optimization of drug candidates, leading to the discovery of more effective and safer therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 454701-66-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,4,7,0 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 454701-66:
(8*4)+(7*5)+(6*4)+(5*7)+(4*0)+(3*1)+(2*6)+(1*6)=147
147 % 10 = 7
So 454701-66-7 is a valid CAS Registry Number.
454701-66-7Relevant academic research and scientific papers
Synthesis and biological evaluation of heteroalicyclic cyanoguanidines at histamine receptors
Soliman, Beatrice,Wang, Ning,Zagotto, Giuseppe,Pockes, Steffen
, (2019/08/12)
Recent studies on histamine receptor (HR) subtypes identified imidazolyl butyl cyanoguanidines, like UR-PI376, as highly potent agonists at the human histamine H4 receptor (hH4R). While imidazole-containing compounds display drawbacks in pharmacokinetics, we studied the possibility of?replacing?the heteroaromatic cycle by nonaromatic six-membered heterocycles (piperidine, morpholine, thiomorpholine, and?N-methylpiperazine) as potential bioisosteres. Beyond that, this approach should give more information about the indispensability of the?aromatic ring as a basic head group. Besides these changes, a variation of the spacer length (C3–C5) connecting the heterocycle and the cyanoguanidine moiety has been made to possibly trigger the selectivity towards the respective HRs. Investigations in radioligand-binding assays exhibited only very weak activity at the hH1R and hH3R, while nearly all compounds were inactive at the hH2R and hH4R. In the case of piperidine-containing compounds, moderate affinities at the hH3R over the single-digit micromolar range were detected.
OMEGA-AMINOALKYLAMIDES OF (R)-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF THE CHEMOTAXIS OF POLYMORPHONUCLEATE AND MONONUCLEATE CELLS
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Paragraph 0083, (2016/08/23)
no abstract published
