455281-60-4Relevant academic research and scientific papers
Anionic amphiphilic dendrimers as antibacterial agents
Meyers, Steven R.,Juhn, Frank S.,Griset, Aaron P.,Luman, Nathanael R.,Grinstaff, Mark W.
, p. 14444 - 14445 (2008)
An anionic amphiphilic dendrimer is reported that possesses increased cytotoxicological potency against prokaryotic cells compared to eukaryotic cells. The half-maximal effective concentration (EC50) for the dendrimer against Bacillus subtilis, a Gram-positive bacterial strain, was measured to be 4.1 × 10-5 M, while that against human umbilical vein endothelial cells (HUVEC) was more than 36× greater at a value of 1.5 × 10-3 M. EC50 ratios for two commercial amphiphiles, sodium dodecyl sulfate (SDS) and Triton X-100, in addition to a similar synthesized dendritic structure were at most only 3.8× greater. Furthermore, the observed EC50 values appear to be correlated to the critical aggregation constant (CAC) in solution suggesting a mechanism of action for these anionic amphiphilic dendrimers related to their supramolecular structures. Copyright
The Convergent Synthesis of Poly(glycerol-succinic acid) Dendritic Macromolecules
Luman, Nathanael R.,Smeds, Kimberly A.,Grinstaff, Mark W.
, p. 5618 - 5626 (2007/10/03)
The high-yield convergent synthesis of dendrons, dendrimers, and dendritic-linear hybrid macromolecules composed of succinic acid, glycerol, and poly(ethylene glycol) (PEG) is described. This convergent synthesis relies on two orthogonal protecting groups
