455330-80-0

Upstream product

• 75534-35-9 2-(2-bromo-5-methoxyphenyl)ethan-1-ol 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 153683-14-8 2-(2-Bromo-5-methoxyphenyl)-1-iodoethane 
• 10468-40-3 cyclohexanone N-cyclohexylimine 

Downstream Products

• 480432-55-1 2-bromo-2-phenylethynylcyclohexanone 
• 823809-74-1 2-bromo-2-[2-(2-bromo-5-methoxyphenyl)ethyl]cyclohexanone 
• 455331-02-9 6-[2-(2-bromo-5-methoxyphenyl)ethyl]-7-(nitromethyl)-1,4-dioxaspiro[4,5]decane 
• 455330-75-3 6-[2-(2-bromo-5-methoxyphenyl)ethyl]-1,4-dioxaspiro[4,5]decane-7-carboxaldehyde 
• 455330-81-1 2-[2-(2-bromo-5-methoxy-phenyl)-ethyl]-3-nitromethyl-cyclohexanone 
• 480432-73-3 2-[2-(2-bromo-5-methoxyphenyl)ethyl]cyclohexenone 

Relevant academic research and scientific papers

Enantioselective Construction of Spiro Quaternary Carbon Stereocenters via Pd-Catalyzed Intramolecular α-Arylation

We herein report the development of a sterically hindered and electron-rich P-chiral monophosphorus biaryl ligand that has enabled a general and efficient enantioselective intramolecular α-arylation, providing access to a wide series of [4.4], [4.5], and [4.6]-spirocycles with chiral benzylic quaternary carbons in high yields with good to excellent enantioselectivities. A pronounced water effect on enantioselectivity is observed.

Palladium-catalyzed intramolecular α-arylation of aliphatic ketone, formyl, and nitro groups

Intramolecular arylation of properly designed substrates bearing a ketone, formyl, or nitro terminating group was achieved by use of a PdCl 2(Ph3P)2-Cs2CO3 reaction system to form a variety of carbocyclic compounds. Arylation in ketone compounds afforded benzene-annulated bridged or spirocycloalkanone derivatives, depending on the structure of the cyclization precursors. Arylation in formyl compounds occurred at the α-position (α-arylation) or at the carbonyl carbon (carbonyl-arylation) depending on the structure of the cyclization precursors and on the reaction solvent. An α-arylated secondary nitro group was partially transformed to ketone in the manner of the Nef reaction, whereas a tertiary nitro group was partially eliminated to afford a styrene-type olefin. Graphical Abstract

Synthesis of a compound having the essential structural unit for the hetisine-type of aconite alkaloids

A hexacyclic compound 1, which carries an almost full structure of the hetisine skeleton lacking only the six-membered ring with an exo methylene group, was synthesized by applying an acetal-ene reaction on 5 for the bond formation of C-14 and C-20 as wel