4558-90-1Relevant academic research and scientific papers
Decarboxylative trifluoromethylthiolation of pyridylacetates
Kawanishi, Ryouta,Nakada, Kosuke,Shibatomi, Kazutaka
supporting information, p. 229 - 233 (2021/02/27)
Decarboxylative trifluoromethylthiolation of lithium pyridylacetates was achieved using N-(trifluoromethylthio)benzenesulfonimide as the electrophilic trifluoromethylthiolation reagent. The reaction afforded the corresponding trifluoromethyl thioethers in good yield. Furthermore, the preparation of lithium pyridylacetates by saponification of the corresponding methyl esters and subsequent decarboxylative trifluoromethylthiolation were performed in a one-pot fashion.
Decarboxylative Fluorination of 2-Pyridylacetates
Kawanishi, Ryouta,Phongphane, Lacksany,Iwasa, Seiji,Shibatomi, Kazutaka
supporting information, p. 7453 - 7456 (2019/05/06)
Syntheses of substituted pyridines and fluorinated compounds, which are often pharmaceutical targets, are important objectives in organic chemistry. Herein, we found that decarboxylative fluorination of lithium 2-pyridylacetates occur under catalyst-free conditions. The phenomenon can be applied to one-pot transformation of substituted methyl 2-pyridylacetate to 2-(fluoroalkyl)pyridine by decarboxylative fluorination of the intermediate lithium 2-pyridylacetate. This method was also applied to the syntheses of 2-(difluoroalkyl)pyridines.
