4561-06-2

Basic information

• Product Name: 2-ETHOXYCARBONYL-ETHYL-PHTHALIMIDE
• Synonyms: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONIC ACID ETHYL ESTER;2-ETHOXYCARBONYL-ETHYL-PHTHALIMIDE;ETHYL 3-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPANOATE
• CAS NO: 4561-06-2
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.25
• Mol File: 4561-06-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-ETHOXYCARBONYL-ETHYL-PHTHALIMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHOXYCARBONYL-ETHYL-PHTHALIMIDE(4561-06-2)
• EPA Substance Registry System: 2-ETHOXYCARBONYL-ETHYL-PHTHALIMIDE(4561-06-2)

Safety Data

• Hazardous Substances Data: 4561-06-2(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 3518-88-5 3,3'-imino-di-propionic acid diethyl ester 
• 136918-14-4 phthalimide 
• 140-88-5 ethyl acrylate 
• 539-74-2 Ethyl 3-bromopropionate 
• 1074-82-4 potassium phtalimide 
• 64-17-5 ethanol 
• 19791-68-5 1-diazo-3-phthalimidopropan-2-one 
• 3339-73-9 3-phthalimidopropanoic acid 
• 4702-13-0 N-phthaloylglycine 
• 6780-38-7 N-phthaloylglycine chloride 
• 115029-07-7 C₁₄H₁₃NO₄S₂ 

Downstream Products

• 83747-30-2 3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionic acid 

Relevant articles and documents

Synthesis of novel isoindolone derivatives via cascade reactions. Contrasting diastereoselectivity under solution-phase vis-a-vis solvent-free ball-milling reaction conditions

The highly diastereoselective synthesis, crystallographic analysis, and full characterization of several novel heterocycle-fused isoindolones is described. The synthetic strategy involves a cascade Michael/aldol-like cyclization reaction between N-substituted phthalimides rac-1 or 2 and several α,β-unsaturated electrophiles to afford the tricyclic systems pyrrolo[2,1- a]isoindolone and tetrahydropyrido[2,1-a]isoindolone. This synthetic strategy offers a convenient alternative to existing procedures for the preparation of isoindolone derivatives fused to five- and six-membered rings. X-ray crystallographic analysis allowed the determination of relative configurations and revealed that the synthesized compounds exhibit significant structural distortion, especially in the five membered rings. Relevantly, the diastereomeric distribution of products depends substantially on whether the cascade reaction is carried out under solution vis-a-vis solvent-free conditions.

Potassium Hydroxide-Catalyzed Chemoselective Reduction of Cyclic Imides with Hydrosilanes: Synthesis of ω-Hydroxylactams and Lactams

Potassium hydroxide-catalyzed hydrosilylation exhibits excellent activity and chemoselectivity for the reduction of cyclic imides under mild reaction conditions. The chemoselectivity of the reduction system may be readily tuned by changing the identity an

Highly efficient KF/Al2O3-catalyzed versatile hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles to α,β-ethylenic compounds

The first example of KF/Al2O3-catalyzed versatile hetero-Michael addition reaction of nitrogen, oxygen, and sulfur nucleophiles was developed for facile preparation of organic compounds of widely different structures. In contrast with the existing methods using many acidic catalysts, this method is very general, simple, high-yielding, environmentally friendly, and oxygen and moisture tolerant.