4569-82-8

Usage

Uses

2-Phenyl-1,3-thiazolane is used for synthesis of thiazolines.

Synthesis Reference(s)

Journal of the American Chemical Society, 79, p. 4716, 1957 DOI: 10.1021/ja01574a036

InChI:InChI=1/C9H11NS/c1-2-4-8(5-3-1)9-10-6-7-11-9/h1-5,9-10H,6-7H2

Upstream product

• 100-52-7 benzaldehyde 
• 60-23-1 Cysteamine 
• 156-57-0 2-mercaptoethylamine hydrochloride 

Downstream Products

• 7738-98-9 benzylidene-(2-benzylsulfanyl-ethyl)-amine 
• 7782-02-7 3-(2-mercapto-ethyl)-2-phenyl-thiazolidin-4-one 
• 21675-08-1 6-cyano-5-oxo-7-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-8-carboxylic acid ethyl ester 
• 7739-03-9 [2-(2,4-Dinitro-phenylsulfanyl)-ethyl]-[1-phenyl-meth-(E)-ylidene]-amine 
• 67189-35-9 3-methyl-2-phenyl-thiazolidine-2-carbonitrile 
• 7739-02-8 (2-Methylsulfanyl-ethyl)-[1-phenyl-meth-(E)-ylidene]-amine 
• 5978-34-7 2-benzylaminoethanethiol 
• 71207-71-1 2-Phenyl-thiazolidine-3-carboxylic acid propylamide 
• 3790-45-2 1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline 
• 84833-12-5 2-Phenyl-thiazolidine-3-carboxylic acid (3-chloro-4-methyl-phenyl)-amide 
• 127084-53-1 C₂₁H₃₉NSSn 
• 84833-10-3 2-Phenyl-thiazolidine-3-carboxylic acid (4-chloro-phenyl)-amide 
• 84833-09-0 2-Phenyl-thiazolidine-3-carboxylic acid phenylamide 
• 145224-22-2 3-<(ethoxycarbonyl)methyl>-2-phenylthiazolidine 

Relevant academic research and scientific papers

First example of the ring-opening transformation of thiazolidines to iminothiols on gold surface

A new way to construction of the self-assembling monolayers on gold surfaces based on ring opening reactions of thiazolidines to iminothiols followed by Au-S bond formation has been proposed.

Sequential ring expansion and ketene elimination reactions in the novel rhodium(I)-catalyzed carbonylation of thiazolidines

1,3-Thiazolidines react with carbon monoxide, in the presence of catalytic quantities of chloro(1,5-cyclooctadiene)rhodium(I) dimer and potassium iodide, to give thiazolidinones in 56-88% yields. Reaction in the absence of KI afforded the six-membered ring thiazin-3-one. The rhodium(I) complex can catalyze the quantitative conversion of the thiazin-3-one to the thiazolidinone under carbon monoxide, with ketene as the reaction by-product. The conversion of thiazolidines to thiazolidinones involves a novel regiospecific insertion of carbon monoxide into one of two ring carbon-nitrogen bonds, as well as a metal-catalyzed ketene elimination process.

Dopamine-beta-hydroxylase inhibitors

Dopamine-β-hydroxylase inhibitors of structure: Pharmaceutical compositions containing them and their use in methods of lowering blood pressure in mammals.

RING-CHAIN TAUTOMERISM IN 1,3-THIAZOLIDINES

NMR spectroscopy was applied to study ring-chain tautomeric equilibria in several substituted 1,3-thiazolidines.The system highly prefers the ring form and only in the case of 2-(2'-hydroxy-5'-bromophenyl)-1,3-benzothiazoline (2d) 1H and 13C NMR spectra r

SELECTIVE DESULFURIZATION OF 1,3-DITHIANES, -OXATHIOLANES AND -THIAZOLIDINES BY TRIBUTYLTIN HYDRIDE

Selective desulfurization of 2-alkyl-1,3-dithianes, -oxathiolanes, or -thiazolidines 1 with one equivalent of tri-n-butyltin hydride yields acyclic compounds R1R2CHX(CH2)nSSnBu3 (X=S,O,NH; n=2,3), (2) which can be destannylated to the corresponding mercaptans 3.

Preparation of thiazolidine derivatives

A method of preparing a thiazolidine derivative of the formula STR1 where R, R1, R2 R3 and R4 are each independently hydrogen or appropriate aromatic or aliphatic substituents, comprises reacting together a sulp

Comparative radioprotective activity of various pentagonal compounds with two heteroatomes

Various heterocyclic compounds with two heteroatomes were synthesized and their potential radioprotective activity was tested. This study shows the interest of phenylthiazolidines derivatives in chemical radioprotection.

1H NMR STRUCTURAL STUDY OF 2-PHENYLTHIAZOLIDINE

Deuteration of 2-phenylthiazolidine, and its complexation with the shift reagent tris(1,1,1,2,2,3,3-heptafluoro-7,7-dimethyl-4,6-octanedionato)europium, have been used to study the signals and conformation of the heterocyclic protons and to interpret the 1H NMR spectrum of this 2-substituted thiazolidine.