2-Phenylthiazolidine

Base Information

• Chemical Name: 2-Phenylthiazolidine
• CAS No.: 4569-82-8
• Molecular Formula: C9H11N
• Molecular Weight: 165.259
• Hs Code.: 2934100090
• NSC Number: 357913
• UNII: LP6UVF85UR
• DSSTox Substance ID: DTXSID60903063
• Nikkaji Number: J48.704J
• ChEMBL ID: CHEMBL25250
• Mol file: 4569-82-8.mol

Synonyms:2-phenylthiazolidine

Chemical Property of 2-Phenylthiazolidine

Chemical Property:

• Vapor Pressure: 0.00115mmHg at 25°C
• Melting Point: 110-112 °C
• Refractive Index: 1.585
• Boiling Point: 300.1 °C at 760 mmHg
• Flash Point: 135.3 °C
• PSA: 37.33000
• Density: 1.113 g/cm³
• LogP: 2.35040
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 165.06122053
• Heavy Atom Count: 11
• Complexity: 121

Purity/Quality:

99% ^*data from raw suppliers

2-Phenyl-1,3-thiazolane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CSC(N1)C2=CC=CC=C2
• Uses: 2-Phenyl-1,3-thiazolane is used for synthesis of thiazolines.

Technology Process of 2-Phenylthiazolidine

There total 4 articles about 2-Phenylthiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

benzaldehyde (100-52-7) + Trimethylsilanyl-(2-trimethylsilanylsulfanyl-ethyl)-amine → 2-phenyl-1,3-thiazolidine (4569-82-8) + Hexamethyldisiloxane (107-46-0)

Guidance literature:

at 20 ℃;

DOI:10.1007/BF00952881

Reference yield: 70.0%

benzaldehyde (100-52-7) + Cysteamine (60-23-1) → 2-phenyl-1,3-thiazolidine (4569-82-8)

Guidance literature:

In benzene;

DOI:10.1002/mrc.1270170116

Reference yield:

2-mercaptoethylamine hydrochloride (156-57-0) + benzaldehyde (100-52-7) → 2-phenyl-1,3-thiazolidine (4569-82-8)

Guidance literature:

With sodium hydroxide; In ethanol; for 1h; Heating;

DOI:10.1248/cpb.35.1953

upstream raw materials:

benzaldehyde

Cysteamine

2-mercaptoethylamine hydrochloride

Downstream raw materials:

2-Phenyl-thiazolidine-3-carboxylic acid propylamide

1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline

2-Phenyl-thiazolidine-3-carboxylic acid (3-chloro-4-methyl-phenyl)-amide

C₂₁H₃₉NSSn

Refernces

• 1、 Khumtaveeporn, Kanjai,Alper, Howard. "Sequential ring expansion and ketene elimination reactions in the novel rhodium(I)-catalyzed carbonylation of thiazolidines". . p. 5662 - 5666. Retrieved 2007/10/02.
• 2、 -. "Dopamine-beta-hydroxylase inhibitors". . . Retrieved 2008/06/13.