457-49-8 Usage
General Description
Cyclohexyltrifluoroacetone is a chemical compound with the molecular formula C9H11F3O. It is a colorless liquid with a strong, sweet odor, and it is commonly used as a solvent and reagent in various chemical reactions. Cyclohexyltrifluoroacetone is known for its ability to form stable complexes with metal ions, making it useful in the extraction and separation of metals. It is also used in the production of pharmaceuticals and as a building block in organic synthesis. Additionally, it is known for its high reactivity and ability to undergo various chemical transformations, making it a versatile and valuable compound in the field of organic chemistry. Overall, cyclohexyltrifluoroacetone is a versatile and important compound with a wide range of industrial and research applications.
Check Digit Verification of cas no
The CAS Registry Mumber 457-49-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 457-49:
(5*4)+(4*5)+(3*7)+(2*4)+(1*9)=78
78 % 10 = 8
So 457-49-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H13F3O/c10-9(11,12)8(13)6-7-4-2-1-3-5-7/h7H,1-6H2
457-49-8Relevant articles and documents
Stereoconvergent negishi arylations of racemic secondary alkyl electrophiles: Differentiating between a CF3 and an alkyl group
Liang, Yufan,Fu, Gregory C.
supporting information, p. 9523 - 9526 (2015/08/18)
In this report, we establish that a readily available nickel/bis(oxazoline) catalyst accomplishes a wide array of enantioconvergent cross-couplings of arylzinc reagents with CF3-substituted racemic secondary alkyl halides, a process that necessitates that the chiral catalyst be able to effectively distinguish between a CF3 and an alkyl group in order to provide good ee. We further demonstrate that this method can be applied without modification to the catalytic asymmetric synthesis of other families of fluorinated organic compounds.
A Weinreb amide approach to the synthesis of trifluoromethylketones
Rudzinski, Diandra M.,Kelly, Christopher B.,Leadbeater, Nicholas E.
supporting information, p. 9610 - 9612 (2012/10/29)
A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.
