457049-19-3

Basic information

• Product Name: 7-(benzyloxy)-2,2-diethoxy-3,4-dihydro-2H-naphtho[1,2-b]pyran
• Synonyms: 7-(benzyloxy)-2,2-diethoxy-3,4-dihydro-2H-naphtho[1,2-b]pyran
• CAS NO: 457049-19-3
• Molecular Weight: 378.468
• Mol File: 457049-19-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(benzyloxy)-2,2-diethoxy-3,4-dihydro-2H-naphtho[1,2-b]pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(benzyloxy)-2,2-diethoxy-3,4-dihydro-2H-naphtho[1,2-b]pyran(457049-19-3)
• EPA Substance Registry System: 7-(benzyloxy)-2,2-diethoxy-3,4-dihydro-2H-naphtho[1,2-b]pyran(457049-19-3)

Safety Data

• Hazardous Substances Data: 457049-19-3(Hazardous Substances Data)

Upstream product

• 42216-96-6 triethyl orthoacrylate 
• 109972-84-1 1-Benzyloxy-5-hydroxynaphthalene 
• 83-56-7 1,5-dihydroxynaphthalene 
• 100-39-0 benzyl bromide 

Downstream Products

• 457049-23-9 5-(benzyloxy)-1,4-dimethoxynaphthalene-2-propanoic acid 
• 457049-22-8 ethyl 5-(benzyloxy)-1,4-dihydro-1,4-dioxonaphthalene-2-propanoate 
• 457049-20-6 ethyl 5-(benzyloxy)-1-hydroxynaphthalene-2-propanoate 

Relevant articles and documents

Synthetic studies on kinamycin antibiotics: Synthesis of a trioxygenated benz[f]indenone and its Diels-Alder reaction to a kinamycin skeleton

A benzo[b]fluorene skeleton such as 10, a basic four-ring system in the revised diazo structures 3 of kinamycin antibiotics, was synthesized by Diels-Alder reaction between dienophile 4,7,8-trioxygenated 1H-benz[f]inden-1-one 11 and Danishefsky-type diene 7. The indenone 11 was prepared by deoxygenation of 2,3-dihydro-1H-benz[f]inden-1-one 12 with the inexpensive 1 -hydroxy-1.2-benziodoxol-3(1H)-one 1-oxide (IBX) after modification of the known protocol. Indenone 12 in turn was obtained from naphthalene-1,5-diol (14) via an intramolecular Friedel-Crafts cyclization of naphthalene-2-propanoic acid 13 as a key step.