457073-91-5

Upstream product

• 100-39-0 benzyl bromide 
• 457073-87-9 (R)-1-tert-butyldimethylsiloxy-6-methylene-oct-7-en-4-ol 
• 457073-89-1 (R)-4-benzyloxy-6-methylene-oct-7-en-1-ol 
• 78-79-5 isoprene 
• 128386-22-1 (2-Methylene-but-3-enyl)-bis-((1S,2R,3S,5S)-2,6,6-trimethyl-bicyclo[3.1.1]hept-3-yl)-borane 
• 457073-88-0 (R)-1-tert-butyldimethylsiloxy-4-benzyloxy-6-methylene-8-octene 
• 457073-90-4 (R)-4-benzyloxy-6-methylene-oct-7-enoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 457073-92-6 (R)-N-hydroxy-4-benzyloxy-6-methylene-7-octenamide 

Relevant academic research and scientific papers

Type 2 Intramolecular N-Acylnitroso Diels-Alder Reaction: Scope and Application to the Synthesis of Medium Ring Lactams

Heteroatom variants of the type 2 intramolecular Diels-Alder reaction provide an efficient method for the preparation of bridged bicyclic heterocycles. The type 2 variant of the intramolecular N-acylnitroso Diels-Alder reaction is an effective method for

Type 2 intramolecular N-acylnitroso diels-alder reaction: stereoselective synthesis of bridged bicyclic oxazinolactams.

[reaction: see text] The type 2 intramolecular N-acylnitroso Diels-Alder reaction has been employed for the synthesis of substituted bridged bicyclic oxazinolactams. Upon oxidation of hydroxamic acid 6, a 3-benzylated oxazinolactam (7) was synthesized with complete diastereoselectivity. Elaboration of cycloadduct 7 liberated a cis-3,7-disubstituted azocin-2-one (9).