457081-01-5Relevant articles and documents
Photochemical preparation of a pyridone containing tetracycle: A Jak protein kinase inhibitor
Thompson, James E.,Cubbon, Rose M.,Cummings, Richard T.,Wicker, Linda S.,Frankshun, Robert,Cunningham, Barry R.,Cameron, Patricia M.,Meinke, Peter T.,Liverton, Nigel,Weng, Youmin,DeMartino, Julie A.
, p. 1219 - 1223 (2002)
Jak3 is a protein tyrosine kinase that is associated with the shared γ chain of receptors for cytokines IL2, IL4, IL7, IL9, and IL13. We have discovered that a pyridone-containing tetracycle (6) may be prepared from trisubstituted imidazole (5) in high yi