461-87-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-4-methylpyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its unique structure allows for the development of new drugs with improved properties, such as increased potency, selectivity, and reduced side effects.
Used in Chemical Synthesis:
2-Fluoro-4-methylpyridine is used as a building block in the preparation of a variety of chemical compounds, including:
1. 2-Fluoro-4-(iodomethyl)pyridine: 2-Fluoro-4-methylpyridine can be used in further organic synthesis and as a precursor for the development of new pharmaceutical agents.
2. 4-(4-fluorophenyl)-5-(2-fluoropyridin-4-yl)-1,3-dihydroimidazol-2-thione: 2-Fluoro-4-methylpyridine may have potential applications in medicinal chemistry and drug discovery.
3. 2-fluoro-4-pyridinemethanol: 2-Fluoro-4-methylpyridine can be used in the synthesis of various pyridine-based derivatives with potential applications in pharmaceuticals and materials science.
4. 2-fluoro-4-pyridinemethanol, 4-methylbenzenesulfonate: This ester derivative can be used in the synthesis of other pyridine-based compounds and as a reagent in organic chemistry.
5. 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone: 2-Fluoro-4-methylpyridine may have potential applications in materials science, such as in the development of new organic materials with unique properties.
6. 2-fluoro-3-iodo-5-methylpyridine: 2-Fluoro-4-methylpyridine can be used as a precursor in the synthesis of other pyridine-based compounds and as a building block in organic chemistry.
7. 2-fluoro-4-pyridinecarboxylic acid: 2-Fluoro-4-methylpyridine can be used in the synthesis of various pyridine-based derivatives, including pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 108-89-4 picoline 
• 75-05-8 acetonitrile 
• 116241-53-3 1-fluoro-4-methylpyridinium tetrafluoroborate 
• 4926-28-7 2-Bromo-4-picoline 

Downstream Products

• 402-65-3 2-fluoropyridine-4-carboxylic acid 
• 13466-41-6 4-methyl-1H-pyridin-2-one 
• 215674-15-0 2-fluoro-4-(iodomethyl)-pyridine 
• 188345-23-5 2-(2-Fluoropyridin-4-yl)-1-(3-trifluoromethylphenyl)-ethanone 
• 260981-46-2 2-methyl-2-(4-methylpyridin-2-yl)propanenitrile 
• 383426-35-5 (4-Methyl-pyridin-2-yl)-((S)-1-phenyl-ethyl)-amine 
• 302839-09-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)ethan-1-one 
• 3475-21-6 4-methyl-2-phenylpyridine 
• 303162-49-4 2-(2-fluoro-pyridin-4-yl)-1-(3-methylphenyl)ethanone 
• 383426-37-7 (2-fluoropyridin-4-yl)methan-N-hydroxyimine 
• 131747-60-9 (2-fluoropyridin-4-yl)methanol 
• 913706-47-5 2-fluoro-4-[2-methylsulfanyl-5-(3-trifluoromethylphenyl)-3H-imidazol-4-yl]pyridine 
• 189442-95-3 1-(2-fluoropyridin-4-yl)-2-<3-(trifluoromethyl)phenyl>ethane-1,2-dione 1-oxime 
• 457081-00-4 1-(4-fluorophenyl)-2-(2-fluoropyridin-4-yl)-2-(hydroxyimino)-ethan-1-one 

Relevant academic research and scientific papers

Rapid and efficient synthesis of [18F]fluoronicotinamides, [18F]fluoroisonicotinamides and [18F]fluorobenzamides as potential pet radiopharmaceuticals for melanoma imaging

In an attempt to simplify nucleophilic radiofluorination reactions to be amenable for automation, a series of [18F]fluoronicotinamides, [ 18F]fluoroisonicotinamides and [18F]fluorobenzamides were synthesized using one-step

Microwave-assisted synthesis of substituted fluoroazines using KF·2H2O

This Letter describes a new microwave-assisted fluorination of azines using hydrated potassium fluoride in untreated DMSO under atmospheric conditions. It is thought that microwave irradiation promotes desolvation of the fluorine anion leading to halide n

JNK INHIBITOR

The present invention relates to a c-Jun N-terminal kinase inhibitor containing an azole compound (I) substituted by a nitrogen-containing aromatic group having substituent(s)(except a compound represented by the formula: ) or a salt thereof or a prodrug thereof.

Bis-acyloxymethyl derivatives

This invention relates to new pyridyl, quinoline and acridine bis-acyloxymethyl compounds; to compositions comprising these compounds; and to processes for their utility as fungicides, bactericides and as inhibitors of the growth of cancer in warm-blooded animals. In accordance with this invention, new bis-acyloxymethyl derivatives are provided of the formula: STR1 wherein B is selected from substituted and unsubstituted alkyl, cycloalkyl, aryl, alkenyl, cycloalkenyl and alkynyl; A is selected from hydrogen and B; or, A and B together comprise a pyrrolizine; L is selected from STR2 wherein Y is selected from hydrogen or STR3 each R and Z is independently selected from hydrogen or substituted and unsubstituted alkyl, cycloalkyl, aryl, alkenyl, cycloalkenyl, alkynyl, amine group, each Z' is independently selected from hydrogen and substituted or unsubstituted alkyl; M is Z or is selected from halogen, nitro, hydroxyl, nitrile and substituted or unsubstituted, carboxylic acid group, carboxylic acid ester group, carboxylic acid amide group, sulfonic acid group and sulfonic acid amide group; ether group, thioether group, acylated hydroxyl, sulfonylamide, sulfonylurea, sulfoxide group, sulfone group and mixtures thereof; each n is the same and is 0 or 1; q is from 0-4; and, X is the anion of an acid.

Carboxamidation of pyridines by the system of elemental fluorine- carbonitrile-water: A useful alternative to the chichibabin amination

The title reaction with pyridine, 4-methylpyridine, 3-methylpyridine, 3- bromopyridine, nicotinonitrile, and quinoline yields 2-carboxamido derivatives regioselectively. Isoquinoline is amidated at position 1.

Synthesis, Chemistry, and Antineoplastic Activity of α-Halopyridinium Salts: Potential Pyridone Prodrugs of Acylated Vinylogous Carbinolamine Tumor Inhibitors

A series of 4- and 5-methyl>-1H-pyrrolizin-5-yl>-2-halopyridinium iodides were synthesized.The rates of hydrolysis of the α-halopyridinium salts to the corresponding pyridones, and the reactivities of the carbamate moieties were studied as a function of pH, buffer composition, and ionic strength.The 4- and 5-pyrrolizinyl-2-halopyridinium iodides and the corresponding pyridones were evaluated against P388 lymphocytic leukemia in vivo.The α-fluoropyridinium compounds were active but the α-chloro compounds were not.This activity was correlated with the rates of hydrolysis of the α-halopyridinium compounds to the active pyridone.Compounds that were active in the P388 screen were evaluated in L1210 leukemia, M5076 carcinoma, and MX-1 mammary xenograft assays in mice.

Preparation of 2-Fluoropyridines via Base-Induced Decomposition of N-Fluoropyridinium Salts

N-Fluoropyridinium salts with either BF4-, SbF6-, or PF6- as a counteranion were treated with excess base such as triethylamine at room temperature to give 2-fluoropyridine in good yield.This method was succesfully applied to the preparation of 2-fluoropyridine derivatives possessing electron-donating or -withdrawing substituents using substituted N-fluoropyridinium tetrafluoroborates.Pyridine-F2 compounds produced through reactions of pyridines with molecular fluorine were also treated with base to give 2-fluoropyridines but in low yields.These reactions are considered to occur through a carbene mechanism as follows: a novel N-F-containing cyclic carbene (3), generated from the N-fluoropyridinium salts by 2-proton abstraction, reacts with fluorine atoms from counteranions such as BF4-, SbF6-, or PF6-, followed by elimination of F- from the N-F moiety, to yield 2-fluoropyridines.Previously reported findings in reactions of pyridines with molecular fluorine are explained on the basis of this mechanism.

DIRECT FLUORINATION OF SUBSTITUTED PYRIDINES

The direct fluorination of pyridines bearing alkyl, halogen, ester, or ketone functions has been employed to prepare the corresponding 2-fluoro-substituted pyridines.