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2-Pyrimidinamine, 5-chloro-N-methyl(9CI) is a pyrimidine derivative featuring a methyl group and a chlorine atom attached to the nitrogen atom at the 5th position. This chemical compound is recognized for its potential in pharmaceutical research, serving as a key building block for the synthesis of a variety of drug molecules.

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  • 45715-16-0 Structure
  • Basic information

    1. Product Name: 2-Pyrimidinamine, 5-chloro-N-methyl- (9CI)
    2. Synonyms: 2-Pyrimidinamine, 5-chloro-N-methyl- (9CI);5-Chloro-N-MethylpyriMidin-2-aMine
    3. CAS NO:45715-16-0
    4. Molecular Formula: C5H6ClN3
    5. Molecular Weight: 143.57424
    6. EINECS: N/A
    7. Product Categories: PYRIMIDINE
    8. Mol File: 45715-16-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-Pyrimidinamine, 5-chloro-N-methyl- (9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-Pyrimidinamine, 5-chloro-N-methyl- (9CI)(45715-16-0)
    11. EPA Substance Registry System: 2-Pyrimidinamine, 5-chloro-N-methyl- (9CI)(45715-16-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 45715-16-0(Hazardous Substances Data)

45715-16-0 Usage

Uses

Used in Pharmaceutical Research:
2-Pyrimidinamine, 5-chloro-N-methyl(9CI) is utilized as a synthetic precursor for the development of novel drug molecules. Its unique chemical structure and properties contribute to its versatility in the creation of therapeutic agents targeting a range of diseases.
Used in Drug Development for Cancer Treatment:
In the field of oncology, 2-Pyrimidinamine, 5-chloro-N-methyl(9CI) is employed as a component in the formulation of anticancer drugs. Its potential applications in treating various types of cancer are currently under investigation, leveraging its chemical properties to target and combat cancer cells.
Used in Drug Development for Infectious Diseases:
Beyond oncology, 2-Pyrimidinamine, 5-chloro-N-methyl(9CI) also shows promise in the development of treatments for infectious diseases. Its incorporation into drug molecules aims to address the challenges posed by various pathogens, offering new avenues for therapeutic intervention.
Used in Medicinal Chemistry:
2-Pyrimidinamine, 5-chloro-N-methyl(9CI) is a valuable asset in medicinal chemistry, where it is used to explore and enhance the properties of drug candidates. Its reactivity and structural features make it instrumental in the optimization of pharmaceutical compounds for improved efficacy and safety.

Check Digit Verification of cas no

The CAS Registry Mumber 45715-16-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,5,7,1 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 45715-16:
(7*4)+(6*5)+(5*7)+(4*1)+(3*5)+(2*1)+(1*6)=120
120 % 10 = 0
So 45715-16-0 is a valid CAS Registry Number.

45715-16-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-chloro-N-methylpyrimidin-2-amine

1.2 Other means of identification

Product number -
Other names 2-PYRIMIDINAMINE,5-CHLORO-N-METHYL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:45715-16-0 SDS

45715-16-0Downstream Products

45715-16-0Relevant articles and documents

Story of an Age-Old Reagent: An Electrophilic Chlorination of Arenes and Heterocycles by 1-Chloro-1,2-benziodoxol-3-one

Wang, Mengzhou,Zhang, Yanyan,Wang, Tao,Wang, Chao,Xue, Dong,Xiao, Jianliang

supporting information, p. 1976 - 1979 (2016/06/01)

By the use of 1-chloro-1,2-benziodoxol-3-one, an age-old reagent, the practical and efficient chlorination method is achieved. This hypervalent iodine reagent is amenable not only to the chlorination of nitrogen-containing heterocycles but also to selected classes of arenes, BODIPY dyes, and pharmaceuticals. In addition, the advantages, such as easy preparation and recyclable, air- and moisture-stable, in combination with the success in a gram-scale experiment grant this reagent great potential for industrial application.

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