458-06-0Relevant academic research and scientific papers
An air-stable copper reagent for nucleophilic trifluoromethylthiolation of aryl halides
Weng, Zhiqiang,He, Weiming,Chen, Chaohuang,Lee, Richmond,Tan, Davin,Lai, Zhiping,Kong, Dedao,Yuan, Yaofeng,Huang, Kuo-Wei
, p. 1548 - 1552 (2013)
A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF2 with Me3SiCF 3 and S8 (see scheme; Cu red, F green, N blue, S yellow). These air-stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields. Copyright
A new synthesis of trifluoromethyl sulfides utilizing thiocyanates and fluoroform
Potash, Shay,Rozen, Shlomo
, p. 173 - 176 (2015/03/05)
Fluoroform is a potent greenhouse gas which should not be released to the atmosphere. Large amounts of it are stored and wait for new and useful reactions to be based on it. One such general reaction that is described in this paper is its use in preparation of the important organic trifluoromethyl sulfides. Aliphatic, aromatic and heterocyclic thiocyanates are easy to prepare. They were reacted with fluoroform-based CuCF3 to form the corresponding (trifluoromethyl)thio derivatives.
Copper-catalyzed synthesis of aryl and alkyl trifluoromethyl sulfides using CF3SiMe3and Na2S2O3as -SCF3source
Zhong, Wei,Liu, Xiaoming
supporting information, p. 4909 - 4911 (2014/12/10)
A universal and efficient Cu(I)-catalyzed synthesis of aryl and alkyl trifluoromethyl sulfides has been developed. In this catalytic system, S-aryl or S-alkyl sulfothioate (I or II) proved to be the key intermediate. Substrates bearing groups of I, Br, Cl, OTs, and OMs on the aryl carbon and no matter electron-withdrawing and electron-donating substitutions on the aromatic ring could afford good to excellent yields.
