458-10-6

Basic information

• Product Name: N-(3-fluoro-4-methyl-phenyl)acetamide
• Synonyms: N-(3-fluoro-4-methyl-phenyl)acetamide;3'-Fluoro-4'-methylacetanilide;NSC 57471
• CAS NO: 458-10-6
• Molecular Formula: C₉H₁₀FNO
• Molecular Weight: 167.18
• Mol File: 458-10-6.mol

Chemical Properties

• Boiling Point: 296.7°Cat760mmHg
• Flash Point: 133.2°C
• Appearance: /
• Density: 1.169g/cm³
• Vapor Pressure: 0.00141mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: N-(3-fluoro-4-methyl-phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluoro-4-methyl-phenyl)acetamide(458-10-6)
• EPA Substance Registry System: N-(3-fluoro-4-methyl-phenyl)acetamide(458-10-6)

Safety Data

• Hazardous Substances Data: 458-10-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
N-(3-fluoro-4-methyl-phenyl)acetamide is employed as a key building block in the synthesis of potential drug candidates due to its unique molecular structure and properties.
Used in Pain Relief Medications:
N-(3-fluoro-4-methyl-phenyl)acetamide is used as a starting material for developing new pain-relief medications, capitalizing on its analgesic properties to alleviate discomfort and pain.
Used in Anti-inflammatory Agents:
Leveraging its anti-inflammatory characteristics, N-(3-fluoro-4-methyl-phenyl)acetamide contributes to the creation of medications designed to reduce inflammation and associated symptoms.
Used in Organic Compounds Synthesis:
Beyond its medicinal applications, N-(3-fluoro-4-methyl-phenyl)acetamide is utilized as an intermediate in the manufacture of other organic compounds, showcasing its broad applicability in the chemical industry.

InChI:InChI=1/C9H10FNO/c1-6-3-4-8(5-9(6)10)11-7(2)12/h3-5H,1-2H3,(H,11,12)

Upstream product

• 452-77-7 3-fluoro-4-methyl-phenylamine 
• 108-24-7 acetic anhydride 
• 1427-07-2 2-fluoro-4-nitrotoluene 
• 75-07-0 acetaldehyde 

Downstream Products

• 202865-76-7 C₉H₉BrFNO 
• 182182-31-6 2-Acetylamino-8-amino-6-fluoro-5-methyl-1-tetralone 
• 143655-58-7 8-Acetylamino-6-fluoro-5-methyl-1-tetralone 
• 446-31-1 2-fluoro-4-aminobenzoic acid 
• 448-25-9 acetic acid-(5-fluoro-4-methyl-2-nitro-anilide) 
• 364-84-1 4-acetamido-2-fluoro benzoic acid 
• 86771-76-8 2-nitro-4-methyl-5-methoxy aniline 
• 428871-69-6 5-fluoro-4-methyl-2-nitro-aniline 

Relevant articles and documents

Intermediate for synthesizing camptothecin derivative as well as preparation method and application thereof

The invention relates to the technical field of organic compound synthesis, in particular to an intermediate for synthesizing a camptothecin derivative as well as a preparation method and applicationof the intermediate. An intermediate A can be obtained by acylation, bromination and cross coupling reaction of 3-fluoro-4-methylaniline. The intermediate A can be used for preparing an intermediate Bso as to further prepare Exatecan mesylate. The intermediate compound B can be obtained by rearrangement reaction of the intermediate A; Exatecan mesylate can be obtained by subjecting the intermediate compound B to alpha-site acetamido and amino deprotection, condensation reaction and hydrolysis reaction. The method has the advantages of low price of reaction initiators, mild reaction conditionsof each step, simplicity and convenience in operation, high yield and suitability for industrial production.

Sulfated choline ionic liquid-catalyzed acetamide synthesis by grindstone method

Sulfated choline ionic liquid (SCIL) has been found to be an efficient solid acid IL catalyst for the protection of amine groups with acetic anhydride under solvent-free grindstone conditions. The attractive features of this new catalytic methodology include its sustainability, facile work-up procedure, economic viability, and biodegradability. The SCIL catalyst was characterized using infrared spectroscopy, wide-angle X-ray scattering analysis, and scanning electron microscopy with energy dispersive X-ray spectroscopy. The catalyst could be reused six times without significant loss in activity. Furthermore, no chromatographic separations were needed to obtain the desired products.

Human sialidase inhibitors: Design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids

Recent advances in the sialidase biology have clarified the role of human sialidases (NEU 1 to NEU4) in the development of various disease states such as cancer, diabetes and arteriosclerosis. Isoform selective human sialidase inhibitors could be a therap

Sulfonamide-based compounds as protein tyrosine kinase inhibitors

Various sulfonamide-based compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.

Pd-catalyzed ortho-selective oxidative coupling of halogenated acetanilides with acrylates

Coupling of different halogenated acetanilides with acrylates using Pd-catalyzed ortho-selective C-H bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron-rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions.