458-10-6

Basic information

• Product Name: N-(3-fluoro-4-methyl-phenyl)acetamide
• Synonyms: N-(3-fluoro-4-methyl-phenyl)acetamide;3'-Fluoro-4'-methylacetanilide;NSC 57471
• CAS NO: 458-10-6
• Molecular Formula: C₉H₁₀FNO
• Molecular Weight: 167.18
• Mol File: 458-10-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 296.7°Cat760mmHg
• Flash Point: 133.2°C
• Appearance: /
• Density: 1.169g/cm³
• Vapor Pressure: 0.00141mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: N-(3-fluoro-4-methyl-phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-fluoro-4-methyl-phenyl)acetamide(458-10-6)
• EPA Substance Registry System: N-(3-fluoro-4-methyl-phenyl)acetamide(458-10-6)

Safety Data

• Hazardous Substances Data: 458-10-6(Hazardous Substances Data)

Usage

General Description

N-(3-fluoro-4-methyl-phenyl)acetamide is an organic compound with the chemical formula C10H11NO2F. It is a white crystalline solid with a molecular weight of 197.2 g/mol. This chemical is often used in medicinal and pharmaceutical research as a building block for the synthesis of potential drug candidates. It possesses analgesic and anti-inflammatory properties, making it a potential candidate for the development of new pain-relief medications. Additionally, it is used as an intermediate in the manufacture of other organic compounds. However, as with all chemicals, proper handling and storage procedures should be followed to ensure safe usage.

InChI:InChI=1/C9H10FNO/c1-6-3-4-8(5-9(6)10)11-7(2)12/h3-5H,1-2H3,(H,11,12)

Upstream product

• 1427-07-2 2-fluoro-4-nitrotoluene 
• 452-77-7 3-fluoro-4-methyl-phenylamine 
• 108-24-7 acetic anhydride 
• 75-07-0 acetaldehyde 

Downstream Products

• 202865-76-7 C₉H₉BrFNO 
• 182182-31-6 2-Acetylamino-8-amino-6-fluoro-5-methyl-1-tetralone 
• 143655-58-7 8-Acetylamino-6-fluoro-5-methyl-1-tetralone 
• 86771-76-8 2-nitro-4-methyl-5-methoxy aniline 
• 428871-69-6 5-fluoro-4-methyl-2-nitro-aniline 
• 448-25-9 acetic acid-(5-fluoro-4-methyl-2-nitro-anilide) 
• 364-84-1 4-acetamido-2-fluoro benzoic acid 
• 446-31-1 2-fluoro-4-aminobenzoic acid 

Relevant articles and documents

Intermediate for synthesizing camptothecin derivative as well as preparation method and application thereof

The invention relates to the technical field of organic compound synthesis, in particular to an intermediate for synthesizing a camptothecin derivative as well as a preparation method and applicationof the intermediate. An intermediate A can be obtained by acylation, bromination and cross coupling reaction of 3-fluoro-4-methylaniline. The intermediate A can be used for preparing an intermediate Bso as to further prepare Exatecan mesylate. The intermediate compound B can be obtained by rearrangement reaction of the intermediate A; Exatecan mesylate can be obtained by subjecting the intermediate compound B to alpha-site acetamido and amino deprotection, condensation reaction and hydrolysis reaction. The method has the advantages of low price of reaction initiators, mild reaction conditionsof each step, simplicity and convenience in operation, high yield and suitability for industrial production.

Human sialidase inhibitors: Design, synthesis, and biological evaluation of 4-acetamido-5-acylamido-2-fluoro benzoic acids

Recent advances in the sialidase biology have clarified the role of human sialidases (NEU 1 to NEU4) in the development of various disease states such as cancer, diabetes and arteriosclerosis. Isoform selective human sialidase inhibitors could be a therap

Pd-catalyzed ortho-selective oxidative coupling of halogenated acetanilides with acrylates

Coupling of different halogenated acetanilides with acrylates using Pd-catalyzed ortho-selective C-H bond activation is reported. The yields of coupled products are low to high depending on the substrate. In general, arenes with electron-rich substituents like methoxy and methyl groups gave higher yields of the coupled products. The presence of the halogen substituent did not interfere with the activation process under these conditions.