4584-68-3

Basic information

• Product Name: 3-BROMO-2-HYDROXY-2,4,6-CYCLOHEPTATRIEN-1-ONE
• Synonyms: 3-BROMO-2-HYDROXY-2,4,6-CYCLOHEPTATRIEN-1-ONE;3-Bromotropolone
• CAS NO: 4584-68-3
• Molecular Formula: C₇H₅BrO₂
• Molecular Weight: 201.0174
• Mol File: 4584-68-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 268.5°C at 760 mmHg
• Flash Point: 116.2°C
• Appearance: /
• Density: 1.862g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: 3-BROMO-2-HYDROXY-2,4,6-CYCLOHEPTATRIEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-HYDROXY-2,4,6-CYCLOHEPTATRIEN-1-ONE(4584-68-3)
• EPA Substance Registry System: 3-BROMO-2-HYDROXY-2,4,6-CYCLOHEPTATRIEN-1-ONE(4584-68-3)

Safety Data

• Hazardous Substances Data: 4584-68-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H5BrO2/c8-5-3-1-2-4-6(9)7(5)10/h1-4H,(H,9,10)

Upstream product

• 533-75-5 2-hydroxy-2,4,6-cycloheptatrien-1-one 
• 3008-39-7 cycloheptane-1,2-dione 
• 721-39-1 7-Brom-2-phenoxy-tropon 

Downstream Products

• 3054-77-1 3-bromo-2-methoxytropone 
• 1728-86-5 2-bromo-7-methoxytropone 
• 65425-62-9 3-methoxy-tropolone 
• 721-41-5 3-phenoxy-tropolone 
• 4636-41-3 3,7-dibromotropolone 
• 363-67-7 3,5,7-tribromotropolone 
• 412313-55-4 (+/-)-3,5,7-tribromo-cyclohepta-3,5-diene-1,2-dione 
• 34777-04-3 3-Hydroxytropolone 
• 98437-35-5 7-Brom-2-methyl-tropon 
• 721-41-5 3-Phenoxy-tropolon 
• 100866-17-9 7-Anilino-2-methyl-tropon 
• 101089-49-0 2-Methyl-7--tropon 
• 724-81-2 2-Phenoxy-7-hydrazino-tropon 
• 717-52-2 2-Phenoxytropolon 

Relevant articles and documents

Studies on the anti-hepatitis C virus activity of newly synthesized tropolone derivatives: Identification of NS3 helicase inhibitors that specifically inhibit subgenomic HCV replication

We synthesized new tropolone derivatives substituted with cyclic amines: piperidine, piperazine or pyrrolidine. The most active anti-helicase compound (IC50= 3.4 μM), 3,5,7-tri[(4′-methylpiperazin-1′-yl) methyl]tropolone (2), inhibited RNA replication by 50% at 46.9 μM (EC 50) and exhibited the lowest cytotoxicity (CC50) >1 mM resulting in a selectivity index (SI = CC50/EC50) >21. The most efficient replication inhibitor, 3,5,7-tri[(4′-methylpiperidin- 1′-yl)methyl]tropolone (6), inhibited RNA replication with an EC 50 of 32.0 μM and a SI value of 17.4, whereas 3,5,7-tri[(3′- methylpiperidin-1′-yl)methyl]tropolone (7) exhibited a slightly lower activity with an EC50 of 35.6 μM and a SI of 9.8.

TROPOLONE DERIVATIVES AND TAUTOMERS THEREOF FOR IRON REGULATION IN ANIMALS

Disclosed are a series of compounds or their tautomers having a general structure represented by Formula (la), (lb), (Ila), (lIb), or (lIc) and pharmaceutically acceptable salts thereof. The present disclosure also relates to pharmaceutical compositions comprising said compounds or tautomers. The present disclosure further relates to a method of treating a disease or condition associated with iron dysregulation or dysfunctional iron homeostasis comprising administering to a subject in need thereof a therapeutically effective amount of Formula (la), (lb), (Ila), (lIb), or (lIc) compounds or tautomers.

Anti-mycoplasma agent

An anti-mycoplasma agent comprising tropolone, its derivatives, represented by the formula: STR1 (wherein R1 is hydroxy, aliphatic acyloxy, arylacyloxy, arysulfonyloxy, carboxyalkyloxy or its ester, benzoylalkyloxy, alkenyloxy, 1,3-dihydro-3-oxo-1-isobenzofuranyloxy, (2-oxo-5-methyl-1,3-dioxol-4-yl)methyloxy or thiocyanato and R2 is hydrogen, halogen, hydroxy, alkyl or alkoxy) and their salts as an active ingredient, which has potent activity especially against tylosin-resistant mycoplasma both in vitro and in vivo and is effectively used in treating the diseases caused thereby.