458532-86-0

Basic information

• Product Name: 2-FLUOROPYRIDINE-4-BORONIC ACID PINACOL ESTER
• Synonyms: 2-FLUORO-4-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE;2-FLUOROPYRIDINE-4-BORONIC ACID PINACOL ESTER;2-Fluoro-4-pyridineboronic acid pinacol ester;2-fluoro-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-Fluoropyridin-4-ylboronic acid pinacol ester
• CAS NO: 458532-86-0
• Molecular Formula: C11H15BFNO2
• Molecular Weight: 223.05
• Mol File: 458532-86-0.mol

Chemical Properties

• Melting Point: 48-52℃
• Boiling Point: 312.1 °C at 760 mmHg
• Flash Point: 142.5 °C
• Appearance: Yellow to beige/Crystals or Powder
• Density: 1.09 g/cm³
• Vapor Pressure: 0.000994mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -1.27±0.10(Predicted)
• CAS DataBase Reference: 2-FLUOROPYRIDINE-4-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROPYRIDINE-4-BORONIC ACID PINACOL ESTER(458532-86-0)
• EPA Substance Registry System: 2-FLUOROPYRIDINE-4-BORONIC ACID PINACOL ESTER(458532-86-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 458532-86-0(Hazardous Substances Data)

Usage

Uses

Used in pharmaceuticals, agrochemicals, and high-tech materials.

InChI:InChI=1/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-14-9(13)7-8/h5-7H,1-4H3

Upstream product

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Downstream Products

• 1499162-60-5 6-(2-fluoro-4-pyridyl)pyrido[3,2-d]pyrimidin-4-amine 

Relevant articles and documents

4-PHENYL-N-(PHENYL)THIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS ARYL HYDROCARBON RECEPTOR (AHR) AGONISTS FOR THE TREATMENT OF E.G. ANGIOGENESIS IMPLICATED OR INFLAMMATORY DISORDERS

4-phenyl-N-(phenyl)thiazol-2-amine and 4-(pyridin-3-yl)-N-( phenyl) thiazol-2-amine derivatives and the corresponding thiadiazole, thiophene, oxazole, oxadiazole, imidazole and triazole derivatives and related compounds as aryl hydrocarbon receptor (AHR) agonists for the treatment of angiogenesis implicated disorders, such as e.g. retinopathy, psoriasis, rheumatoid arthritis, obesity and cancer, or inflammatory disorders.

para-Selective C?H Borylation of (Hetero)Arenes by Cooperative Iridium/Aluminum Catalysis

para-Selective C?H borylation of benzamides and pyridines has been achieved by cooperative iridium/aluminum catalysis. A combination of iridium catalysts commonly employed for arene C?H borylation and bulky aluminum-based Lewis acid catalysts provides an unprecedented strategy for controlling the regioselectivity of C?H borylation to give variously substituted (hetero)arylboronates, which are versatile synthetic intermediates for complex multi-substituted aromatic compounds.

Fluorine-controlled C-H borylation of arenes catalyzed by a PSiN-pincer platinum complex

An efficient, regioselective synthesis of fluorine-substituted arylboronic esters was achieved through fluorine-controlled C-H borylation of arenes with diboron catalyzed by a PSiN-platinum complex. The promising utility of the PSiN-platinum catalyst and its unique regioselectivity were demonstrated for the first time, which would complement the well-developed Ir-catalyzed C-H borylation.

Iridium-catalyzed C-H borylation of pyridines

The iridium-catalysed C-H borylation is a valuable and attractive method for the preparation of aryl and heteroaryl boronates. However, application of this methodology for the preparation of pyridyl and related azinyl boronates can be challenged by low reactivity and propensity for rapid protodeborylation, particularly for a boronate ester ortho to the azinyl nitrogen. Competition experiments have revealed that the low reactivity is due to inhibition of the active catalyst through coordination of the azinyl nitrogen lone pair at the vacant site on the iridium. This effect can be overcome through the incorporation of a substituent at C-2. Moreover, when this is sufficiently electron-withdrawing protodeborylation is sufficiently slowed to permit isolation and purification of the C-6 boronate ester. Following functionalization, reduction of the directing C-2 substituent provides the product arising from formal ortho borylation of an unhindered pyridine ring. This journal is the Partner Organisations 2014.

AMINOQUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES

The invention provides novel compounds having the general formula: wherein A, R1, R2 and R3 are as defined herein, compositions including the compounds and methods of using the compounds.

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Synthesis of novel halopyridinylboronic acids and esters. Part 3: 2, or 3-Halopyridin-4-yl-boronic acids and esters

This paper describes a general method for the synthesis and the isolation of novel 2, or 3-halopyridin-4-yl-boronic acids and esters 12-14, 18-20. These compounds are prepared taking in account a regioselective halogen-metal exchange using nBuLi or direct