458557-46-5

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 930-68-7 cyclohexenone 
• 557-20-0 diethylzinc 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 

Downstream Products

• 478015-73-5 1,1,1-trifluoro-methanesulfonic acid (S)-3-ethyl-cyclohex-1-enyl ester 
• 483339-89-5 (+)-(5(S)-ethylbicyclo[4.1.0]hept-1-yloxy)trimethylsilane 
• 124482-32-2 (+)-3(S)-ethyl-2-methylenecyclohexanone 

Relevant academic research and scientific papers

Tandem Asymmetric Conjugate Addition-Silylation of Enantiomerically Enriched Zinc Enolates. Synthetic Importance and Mechanistic Implications

(Matrix Presented) The zinc enolates, resulting from the copper-catalyzed enantioselective conjugate addition of dialkyl zinc reagents to cyclic and acyclic enones, could be trapped, quantitatively, as silyl enol ethers with TMSOTf in apolar solvents or w

One-pot enantioselective formation of eight-membered rings from alkenyl fischer carbene complexes and ketone enolates

Eight-membered carbocycles with up to five new stereogenic centers are enantioselectively obtained following a one-pot procedure that involves the coupling of three components: an alkenyl Fischer carbene complex, a ketone enolate, and allyl lithium. Copyr

Tandem enantioselective conjugate addition--cyclopropanation. Application to natural products synthesis.

A tandem asymmetric conjugate addition-cyclopropanation was developed, in which a cyclic or linear enone was converted to a TMS-protected 3-substituted-cyclopropanol in an efficient one-pot reaction. These compounds were then selectively cleaved to yield alpha-methyl-beta-alkyl ketones, alpha-methylene-enones, or chain extended gamma-alkyl-enones. This methodology was applied to the formal total synthesis of (-)-(S,S)-clavukerin A and (+)-(R,S)-isoclavukerin.