4586-89-4

Basic information

• Product Name: Benzenebutanoic acid, 4-Methoxy-, ethyl ester
• Synonyms: Benzenebutanoic acid, 4-Methoxy-, ethyl ester
• CAS NO: 4586-89-4
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.28022
• Mol File: 4586-89-4.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenebutanoic acid, 4-Methoxy-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoic acid, 4-Methoxy-, ethyl ester(4586-89-4)
• EPA Substance Registry System: Benzenebutanoic acid, 4-Methoxy-, ethyl ester(4586-89-4)

Safety Data

• Hazardous Substances Data: 4586-89-4(Hazardous Substances Data)

Upstream product

• 4521-28-2 4-(4-Methoxyphenyl)butyric acid 
• 14308-37-3 2,2-Diethoxy-5-(4-methoxy-phenyl)-2,3-dihydro-furan 
• 64-17-5 ethanol 
• 696-62-8 para-iodoanisole 
• 104089-17-0 ethyl 4-(iodozincio)butanoate 
• 6142-64-9 (1R*,2R*)-ethyl 2-(4-methoxyphenyl)cyclopropanecarboxylate 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 7425-53-8 ethyl 4-iodobutyrate 
• 1160755-76-9 p-anisylmethylzinc 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 104-01-8 4-Methoxyphenylacetic acid 
• 854278-66-3 C₁₃H₁₆O₃ 
• 623-73-4 diazoacetic acid ethyl ester 
• 637-69-4 4-Methoxystyrene 

Downstream Products

• 72907-95-0 7-methoxynaphthalene-1,2-dicarboxylic anhydride 
• 7498-68-2 8-methoxy-4,5-dihydronaphtho[1,2-c]furan-1,3-dione 
• 79022-92-7 5-(4-methoxy-phenyl)-2-oxo-valeric acid 
• 73434-22-7 4-(4-Methoxy-phenyl)-2,2-bis-methylsulfanyl-butyric acid ethyl ester 
• 73434-28-3 4-(4-Methoxy-phenyl)-2,2-bis-methylsulfanyl-butyraldehyde 
• 73434-40-9 (E)-ethyl 6-(p-methoxyphenyl)-4-oxo-2-hexenoate 
• 73434-35-2 (E)-6-(4-Methoxy-phenyl)-4,4-bis-methylsulfanyl-hex-2-enoic acid ethyl ester 
• 412322-84-0 C₁₇H₂₂O₆ 
• 1431791-91-1 6-(4-methoxyphenyl)-3-oxohexanenitrile 
• 1431791-15-9 2-diazo-6-(4-methoxyphenyl)-3-oxohexanenitrile 
• 52244-70-9 4-(4-methoxyphenyl)butan-1-ol 
• 6836-19-7 7-Methoxy-1-tetralone 
• 15118-67-9 ethyl 3-(4-methoxybenzoyl)-propionate 
• 128994-28-5 (S)-(-)-γ-(p-Methoxyphenyl)-γ-butyrolactone 

Relevant articles and documents

Mechanical metal activation for Ni-catalyzed, Mn-mediated cross-electrophile coupling between aryl and alkyl bromides

Liquid-assisted grinding has been successfully applied to eliminate the requirements of chemical activators and anhydrous solvents in nickel-catalyzed, manganese-mediated cross-electrophile coupling between aryl and alkyl bromides. In addition to the traditional reaction parameters, mechanical ones,e.g.the rotational speed of mill, the filling degree of jar and ball size, have been found to affect the catalytic efficiency remarkably, implying the involvement of the regeneration of nickel(0) species in the rate-determining steps. A combined evaluation of the reaction and mechanical parameters led to an optimal condition under which a variety ofn-alky aromatics with various functional groups could be readily obtained in good yields with a 1 mol% catalyst loading. The practical application of liquid-assisted grinding-enabled aryl/alkyl cross-electrophile coupling has been demonstrated in the gram-scale synthesis of 6-methoxytetralone.

Visible-light induced metal-free cascade Wittig/hydroalkylation reactions

Cascade reactions are green and powerful transformations for building multiple carbon-carbon bonds in one step. Through a relay olefination and radical addition process, we were able to develop the cascade Wittig/hydroalkylation reactions induced by visible light. This metal-free radical approach features mild conditions, robustness, and excellent functionality compatibility. It allows access to saturated C3 homologation products directly from aldehydes or ketones. The synthetic utility of this method is demonstrated by a two-step synthesis ofindolizidine 209D.

Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Chlorides with Primary Alkyl Chlorides

Alkyl chlorides and aryl chlorides are among the most abundant and stable carbon electrophiles. Although their coupling with carbon nucleophiles is well developed, the cross-electrophile coupling of aryl chlorides with alkyl chlorides has remained a chall