459-06-3

Basic information

• Product Name: 1-Fluoro-4-isopropoxybenzene
• Synonyms: 1-Fluoro-4-isopropoxybenzene;1-Fluoro-4-(1-methylethoxy)-benzene;1-fluoro-4-propan-2-yloxybenzene
• CAS NO: 459-06-3
• Molecular Formula: C₉H₁₁FO
• Molecular Weight: 154.1814432
• Mol File: 459-06-3.mol

Chemical Properties

• Boiling Point: 94 °C(Press: 4 Torr)
• Appearance: /
• Density: 1.0340 g/cm3
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Fluoro-4-isopropoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Fluoro-4-isopropoxybenzene(459-06-3)
• EPA Substance Registry System: 1-Fluoro-4-isopropoxybenzene(459-06-3)

Safety Data

• Hazardous Substances Data: 459-06-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
1-Fluoro-4-isopropoxybenzene is used as a building block in organic synthesis for the production of various organic compounds. Its unique structure and functional groups contribute to the creation of a wide range of chemical products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-Fluoro-4-isopropoxybenzene is used as a building block for the development of new drugs. Its properties make it a promising candidate for the synthesis of medicinal compounds with potential therapeutic applications.
Used in Pesticide Manufacturing:
1-Fluoro-4-isopropoxybenzene is used as a key component in the manufacturing of pesticides and other agricultural chemicals. Its incorporation into these products can enhance their effectiveness in protecting crops and controlling pests.
Used in Materials Science:
In the field of materials science, 1-Fluoro-4-isopropoxybenzene has potential applications due to its unique properties. It can be utilized in the development of new materials with specific characteristics, such as improved stability or reactivity.
Used as a Chemical Reaction Reagent:
Due to its functional groups and reactivity, 1-Fluoro-4-isopropoxybenzene can also serve as a reagent in various chemical reactions. This allows for the synthesis of new compounds and the modification of existing ones, broadening its applications across different industries.

Upstream product

• 371-41-5 4-Fluorophenol 
• 75-26-3 isopropyl bromide 
• 187737-37-7 propene 
• 28530-36-1 1-isopropoxy-4-isopropylbenzene 
• 14366-60-0 1-(tert-butyl)-4-isopropoxybenzene 

Downstream Products

• 371-41-5 4-Fluorophenol 

Relevant articles and documents

Fluorination of 4-alkyl-substituted phenols and aromatic ethers with fluoroxy and N-F reagents: Cesium fluoroxysulfate and N-fluoro-1,4-diazonia- bicyclo[2.2.2]octane dication salts case Dedicated to Prof. Dr. Boris ?emva in honor to his great contribution to fluorine chemistry.

4-Alkyl-substituted phenols and aromatic ethers were comparatively fluorinated with electrophilic fluorinating reagents such as cesium fluoroxysulfate (CFS), Selectfluor F-TEDA-BF4, and Accufluor NFTh in MeCN or MeOH. Reactions resulted in the formation of three types of products: 2-fluoro-4-alkyl-substituted corresponding compounds (5) as a result of ortho fluorination process, 4-alkyl-4-fluoro-cyclohexa-2,5- dienone compounds (6), resulting after an addition-elimination process, and 4-fluorosubstituted corresponding compounds (7) derived from ipso attack and release of the 4-alkyl group. The distribution of products depends on the bulkiness of alkyl groups at both positions and reaction media. The reaction in methanol proved more selective toward the formation of 2-fluoro derivatives. Tyramin and l-tyrozine were transformed with NFTh reagent in methanol to their fluorophenyl-substituted derivatives in good yield.

Iridium-catalyzed, intermolecular hydroetherification of unactivated aliphatic alkenes with phenols

Metal-catalyzed addition of an O-H bond to an alkene is a desirable process because it allows for rapid access to ethers from abundant starting materials without the formation of waste, without rearrangements, and with the possibility to control the stereoselectivity. We report the intermolecular, metal-catalyzed addition of phenols to unactivated α-olefins. Mechanistic studies of this rare catalytic reaction revealed a dynamic mixture of resting states that undergo O-H bond oxidative addition and subsequent olefin insertion to form ether products.