459-26-7

Basic information

• Product Name: 4-Fluorophenetole
• Synonyms: 4-Ethoxyfluorobenzene;Phenetole, p-fluoro-;P-FLUOROPHENETOLE;4-FLUOROPHENETOLE;1-ETHOXY-4-FLUOROBENZENE;1-Ethoxy-4-fluorobenzene 98%;1-Ethoxy-4-fluorobenzene98%;4-Fluorophenetole 98%
• CAS NO: 459-26-7
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.15
• EINECS: 207-287-3
• Product Categories: Phenetole;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds
• Mol File: 459-26-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: -8.5 °C
• Boiling Point: 173 °C / 766mmHg
• Flash Point: 62.3 °C
• Appearance: /
• Density: 1.07
• Vapor Pressure: 1.27mmHg at 25°C
• Refractive Index: gt. 1.4820 to 1.4860
• CAS DataBase Reference: 4-Fluorophenetole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluorophenetole(459-26-7)
• EPA Substance Registry System: 4-Fluorophenetole(459-26-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37/39-27
• HazardClass: IRRITANT
• Hazardous Substances Data: 459-26-7(Hazardous Substances Data)

Usage

General Description

4-Fluorophenetole, also known as p-fluoroanisole, is a chemical compound with the molecular formula C8H9FO. It is a colorless liquid with a sweet, floral odor and is primarily used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. 4-Fluorophenetole is also used in the production of fragrances and flavors due to its pleasant aroma. It is considered to be relatively stable and has low volatility, making it a useful and versatile chemical in various industrial applications. Additionally, it is important to handle 4-Fluorophenetole with care, as it may be hazardous if inhaled or ingested and can cause irritation to the skin and eyes.

InChI:InChI=1/C8H9FO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2H2,1H3

Upstream product

• 371-41-5 4-Fluorophenol 
• 38793-99-6 4-ethoxy-benzenediazonium; chloride 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 
• 540-36-3 para-difluorobenzene 
• 17269-94-2 ethyl p-tert-butylphenyl ether 
• 4132-79-0 4-isopropyl-phenetole 
• 103-73-1 Phenetole 
• 60-29-7 diethyl ether 
• 156-43-4 4-Ethoxyaniline 

Downstream Products

• 371-41-5 4-Fluorophenol 
• 92-69-3 4-Phenylphenol 
• 38751-57-4 2,4-dibromo-phenetole 
• 326-69-2 1-bromo-2-ethoxy-5-fluorobenzene 
• 577793-66-9 5-ethoxy-2-fluoro-phenol 
• 1383479-23-9 C₂₇H₂₉NO₄ 
• 622-62-8 4-Ethoxyphenol 
• 67475-57-4 5-fluoro-2-ethoxybenzenesulfonyl chloride 
• 5710-35-0 2-ethoxy-5-fluorobenzaldehyde 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 405-79-8 2-(4-fluorophenoxy)ethanoic acid 
• 405-51-6 4-fluorophenyl acetate 
• 376601-45-5 (4-cyano-phenylamino)-{3-ethoxy-2-fluoro-5-[(R)-tetrahydro-furan-3-yloxy]-phenyl}-acetic acid ethyl ester 
• 906079-97-8 (4-cyano-phenylamino)-[3-ethoxy-2-fluoro-5-(tetrahydro-furan-3-yloxy)-phenyl]-acetic acid ethyl ester 

Relevant articles and documents

Electrophotocatalytic SNAr Reactions of Unactivated Aryl Fluorides at Ambient Temperature and Without Base

The electrophotocatalytic SNAr reaction of unactivated aryl fluorides at ambient temperature without strong base is demonstrated.

Silver-mediated fluorination of potassium aryltrifluoroborates with Selectfluor Dedicated to Professor Andrea Vasella on the occasion of his 71st birthday

A simple and practical procedure for the silver-mediated fluorination of aryl- and heteroaryltrifluoroborates with electrophilic fluorine from Selectfluor and LiOH·H2O is presented. The reaction procedure is simple and easy to set up, the process produces fluorinated arenes and heteroarenes in good to excellent yields and a wide range of electronically and structurally diverse substrates are tolerated.

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.