459157-20-1

Basic information

• Product Name: 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid
• Synonyms: 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid;4-Oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridine-2-carboxylicacid
• CAS NO: 459157-20-1
• Molecular Formula: C8H8N2O3
• Molecular Weight: 180.16072
• Mol File: 459157-20-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid(459157-20-1)
• EPA Substance Registry System: 4-oxo-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-2- carboxylic acid(459157-20-1)

Safety Data

• Hazardous Substances Data: 459157-20-1(Hazardous Substances Data)

Upstream product

• 37687-24-4 diethyl 1H-pyrazole-3,5-dicarboxylate 
• 459157-16-5 diethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2,5-dicarboxylate 

Relevant articles and documents

Polyheterocyclic substituted pyrimidines or pyridylamine derivatives Composition and medical application thereof

The invention discloses a polycyclic substituted pyrimidine or pyridine amine derivative, and the structure is shown in a formula (I). The invention further discloses a pharmaceutically acceptable salt of the derivative, a solvate, a stereoisomer, a prodrug, a pharmaceutical composition and and an application thereof in medicine. The compounds of the present invention have significant adenosine A. 2A Receptor and/or adenosine A2B The receptor antagonism activity is very practical.

Pyrazolopyrimidine derivatives

The present invention provides a compound of formula (I): where Q is a group of formula: These compounds inhibit cyclic guanosine 3',5'-monophosphate phosphodiesterases (cGMP PDEs). More notably, the compounds are potent and selective inhibitors of the type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases and have utility therefore in a variety of therapeutic areas. In particular, the present compounds are of value for the curative or prophylactic treatment of mammalian sexual disorders.