459453-60-2

Upstream product

• 50-00-0 formaldehyd 
• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 89980-69-8 3,4-dimethoxyphenylmagnesium bromide 
• 870262-21-8 methyl 2-(3,4-dimethoxyphenyl)-2-hydroxypropanoate 

Downstream Products

• 133032-86-7 3,4-dimethoxy-α-methylene benzeneacetic acid 
• 952664-65-2 1-(3,4-dihydroxyphenyl)cyclopropanecarboxylic methyl ester 
• 862574-88-7 1-(2,2-difluorobenzo[1,3]dioxol-5-yl)cyclopropane-1-carboxylic acid 
• 459453-68-0 3-(3,4-dimethoxyphenyl)-5-[(4-methylphenyl)sulfonyl]-1-propyl-1,2,3,4-tetrahydropyridin-2-one 
• 459453-71-5 3-(3,4-dimethoxyphenyl)-1-propylpiperidin-2-one 
• 62033-61-8 3-(3,4-dimethoxyphenyl)-1-propylpiperidine 

Relevant academic research and scientific papers

Electrochemical oxidative: Z -selective C(sp2)-H chlorination of acrylamides

An electrochemical method for the oxidative Z-selective C(sp2)-H chlorination of acrylamides has been developed. This catalyst and organic oxidant free method is applicable across various substituted tertiary acrylamides, and provides access to a broad range of synthetically useful Z-β-chloroacrylamides in good yields (22 examples, 73% average yield). The orthogonal derivatization of the products was demonstrated through chemoselective transformations and the electrochemical process was performed on gram scale in flow.

Cobalt-Catalyzed Vinylic C-H Addition to Formaldehyde: Synthesis of Butenolides from Acrylic Acids and HCHO

A carboxyl-assisted C-H functionalization of acrylic acids with formaldehyde to give butenolides is described. It is the first time that the addition of an inert vinylic C-H bond to formaldehyde has been achieved via cobalt-catalyzed C-H activation. The unique reactivity of the cobalt species was observed when compared with related Rh or Ir catalysts. γ-Hydroxymethylated butenolides were produced by the treatment of Na2CO3 after the catalytic reaction in one pot.

1 - (2, 2 - Difluorobenzene and [d] [1, 3] dioxo heterocyclic pentene - 5 - yl) cyclopropanecarboxylic acid synthetic method and intermediate

The invention belongs to the field of chemical synthesis of drugs, particularly relates to a synthetic method of 1-(2,2-difluoro-benzo[d][1,3]) dioxole-5-yl) cyclopropanecarboxylic acid and an intermediate and aims to provide a synthesis method of a compound (1). The method comprises steps as follows: a, a compound (4) and boron tribromide react, and a compound (3) is synthesized; b, the compound (3) and difluorodibromomethane have a ring closing reaction in the presence of a phase-transfer catalyst, and a compound (2) is synthesized; c, the compound (2) is hydrolyzed, and the compound (1) is synthesized. According to the synthetic method and the intermediate, one novel compound (4) is provided, one novel preparation method of the compound (1) is obtained, with the adoption of the method, not only can the overall yield of the reaction be increased, but also expensive reaction raw materials can be avoided, and the reaction cost is reduced to the great extent; besides, according to the method, utilization of a palladium catalyst and a dangerous sodium cyanide reagent can further be avoided, the safety of pharmaceutical production is guaranteed, and the method is applicable to industrial production.

Copper-Catalyzed Aerobic Decarboxylation/Ketooxygenation of Electron-Deficient Alkenes

A copper-catalyzed ketooxygenation of electron-deficient alkenes was developed. This approach combines O-H alkylation, aerobic decarboxylation, and oxygenation in one transformation. Mechanistic investigation of this reaction showed that the copper salt is responsible for both generating the amidoxyl radical and promoting aerobic decarboxylation.

New synthesis of 3-aryl-N-n-propyl-piperidines

The synthesis of 3-aryl-N-n-propyl-piperidines is described in six steps starting from α-sulfonyl acetamide via the formal [3+3] cycloaddition reaction.