62033-61-8Relevant academic research and scientific papers
New synthesis of 3-aryl-N-n-propyl-piperidines
Chang, Meng-Yang,Chen, Shui-Tein,Chang, Nein-Chen
, p. 3623 - 3628 (2007/10/03)
The synthesis of 3-aryl-N-n-propyl-piperidines is described in six steps starting from α-sulfonyl acetamide via the formal [3+3] cycloaddition reaction.
3-Phenylpiperidines. Central Dopamine-Autoreceptor Stimulating Activity
Hacksell, Uli,Arvidsson, Lars-Erik,Svensson, Uno,Nilsson, J. Lars G.
, p. 1475 - 1482 (2007/10/02)
Thirty compounds related to the selective dopamine-autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine have been synthesized and tested for central dopamine-autoreceptor stimulating activity.The 3-(3-hydroxyphenyl)piperidine moiety seems indispensable for high potency and selectivity.Introduction of an additional hydroxyl group into the 4-position of the aromatic ring gives a compound with dopaminergic activity but lacking selectivity for autoreceptors. 3-(3-Hydroxyphenyl)-N-n-propylpyrrolidine, 3-(3-hydroxy)-N-n-propylperhydroazepine, and 3-(3-hydroxyphenyl)quinuclidine were all inactive.The most potent compounds were the N-isopropyl-, N-n-butyl-, N-n-pentyl-, and N-phenethyl-substituted 3-(3-hydroxyphenyl)piperidine derivatives.None of the compounds investigated seemed to have central noradrenaline- or serotonin-receptor stimulating activity.
3-(3',4'-Disubstituted) phenyl piperidines
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, (2008/06/13)
Novel phenyl piperidines of the formula STR1 wherein X is selected from the group consisting of hydrogen and acyl of an aliphatic carboxylic acid of 2 to 6 carbon atoms and R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, alkenyl o
